Cardiomyocyte-specific CYP2J2 and its therapeutic implications
R Valencia, W Bassiouni, AM Darwesh… - Expert Opinion on …, 2022 - Taylor & Francis
ABSTRACT Introduction Cytochrome P450s (CYPs) are a superfamily of monooxygenases
with diverse biological roles. CYP2J2 is an isozyme highly expressed in the heart where it …
with diverse biological roles. CYP2J2 is an isozyme highly expressed in the heart where it …
Rational deuteration of dronedarone attenuates its toxicity in human hepatic HepG2 cells
LWT Tang, RYR Lim, G Venkatesan… - Toxicology …, 2022 - academic.oup.com
Deuteration is a chemical modification strategy that has recently gained traction in drug
development. The replacement of one or more hydrogen atom (s) in a drug molecule with its …
development. The replacement of one or more hydrogen atom (s) in a drug molecule with its …
Development of Robust 17(R),18(S)-Epoxyeicosatetraenoic Acid (17,18-EEQ) Analogues as Potential Clinical Antiarrhythmic Agents
AM Adebesin, T Wesser, J Vijaykumar… - Journal of Medicinal …, 2019 - ACS Publications
17 (R), 18 (S)-Epoxyeicosatetraenoic acid (EEQ) is a cytochrome P450 metabolite of
eicosapentaenoic acid (EPA) and a powerful negative chronotrope with low nanomolar …
eicosapentaenoic acid (EPA) and a powerful negative chronotrope with low nanomolar …
Amiodarone Advances the Apoptosis of Cardiomyocytes by Repressing Sigmar1 Expression and Blocking KCNH2-related Potassium Channels
H Liang, H Li, F Li, X Xiong… - Current Molecular …, 2024 - ingentaconnect.com
Background: Heart failure (HF) is the ultimate transformation result of various cardiovascular
diseases. Mitochondria-mediated cardiomyocyte apoptosis has been uncovered to be …
diseases. Mitochondria-mediated cardiomyocyte apoptosis has been uncovered to be …
Methods for the Analysis of Arachidonic Acid-Derived Metabolites in Platelets
M Mastrogiovanni, E Fuentes, S Wehinger… - … Applied to Inflammatory …, 2023 - Springer
Arachidonic acid (AA) is the precursor of a series of bioactive lipids with relevant cell
signaling and pathophysiological actions. Arachidonic acid signaling needs the first step of …
signaling and pathophysiological actions. Arachidonic acid signaling needs the first step of …
Dissecting Calcium Rhythms to Predict Arrhythmogenesis in Human Pluripotent Stem Cell Derived Cardiomyocytes Using a Machine Learning Platform
JKS Pang - 2022 - search.proquest.com
The assessment of heart electrophysiology to determine arrhythmia susceptibility in vitro
remains a challenge. Despite the improvements to various platforms used to study …
remains a challenge. Despite the improvements to various platforms used to study …