Abstract The cytochrome P450 (P450) enzymes first attracted interest because of their
relevance to the metabolism of drugs, steroids, and carcinogens. Collectively, the 57 human …

Literature-based knowledge (LBD) discovery is a practical approach to inferring the
associations between diseases and genetic factors from unstructured biomedical data, ie …

Introduction: The aldosterone synthase (CYP11B2)-344T> C gene polymorphism has been
reported to influence the risk of atrial fibrillation (AF) in many studies; however, the results …

The aim of this study is to investigate the effects of CYP11B2 gene polymorphisms with the
adrenocorticotropic hormone (ACTH) and angiotensin II (Ang II) in Chinese patients with …

ABSTRACT Background: Aldosterone synthase (CYP11B2) is a key enzyme involved in the
terminal steps of aldosterone biosynthesis. Genetic variability in CYP11B2 gene has been …

The objective of this study was to examine the extent to which aldosterone synthase
genotype (CYP11B2) and genetic ancestry correlate with atrial fibrillation (AF) and serum …

Background The correlation between CYP11B2 rs1799998 polymorphism and atrial
fibrillation (AF) was analyzed by several studies, but the results of these studies were …

Aldosterone synthase (CYP11B2) is closely linked to essential hypertension (EH). However,
it remains unclear whether the methylation of the CYP11B2 promoter is involved in the …

Background The association between aldosterone synthase (CYP11B2) C-344T gene
polymorphism and ischemic stroke remains controversial and ambiguous. To better explain …

Background: This study investigated the association of angiotensin–converting enzyme
(ACE I/D) and aldosterone synthase (CYP11B2-344C/T) gene polymorphisms in the renin …