The human stress response has evolved to maintain homeostasis under conditions of real or
perceived stress. This objective is achieved through autoregulatory neural and hormonal …

Increasing evidence suggests that mental health and physical health are linked by neural
systems that jointly regulate somatic physiology and high-level cognition. Key systems …

Fatigue is one of the most common adverse effects of cancer that might persist for years after
treatment completion in otherwise healthy survivors. Cancer-related fatigue causes …

Cytokines are pleiotropic molecules with important roles in inflammatory responses. Pro-
inflammatory cytokines and neuroinflammation are important not only in inflammatory …

Because of their potent anti-inflammatory properties, corticosteroids have been used for
decades to treat many diseases, including rheumatic diseases. They are frequently used in …

Enhanced susceptibility to inflammatory and autoimmune disease can be related to
impairments in HPA axis activity and associated hypocortisolism, or to glucocorticoid …

Glucocorticoid action on target tissues is determined by the density of “nuclear” receptors
and intracellular metabolism by the two isozymes of 11β-hydroxysteroid dehydrogenase …

Physical fitness, achieved through regular exercise and/or spontaneous physical activity,
confers resilience by inducing positive psychological and physiological benefits, blunting …

Since the discovery of glucocorticoids in the 1940s and the recognition of their anti-
inflammatory effects, they have been amongst the most widely used and effective treatments …

The secretion of glucocorticoids (GCs) is a classic endocrine response to stress. Despite
that, it remains controversial as to what purpose GCs serve at such times. One view …