Neurodegenerative disorders and type 2 diabetes are global epidemics compromising the
quality of life of millions worldwide, with profound social and economic implications. Despite …

Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of β-cells of
the pancreatic islets of Langerhans. It is a regulatory peptide with putative function both …

Growing scientific literature data suggest that the intake of natural bioactive compounds
plays a critical role in preventing or reducing the occurrence of human chronic non …

Amyloid refers to insoluble protein aggregates that are responsible for amyloid diseases but
are also implicated in important physiological functions (functional amyloids). The …

As the key components of innate immunity, human host defense antimicrobial peptides and
proteins (AMPs) play a critical role in warding off invading microbial pathogens. In addition …

Sequence-specific nucleated protein aggregation is closely linked to the pathogenesis of
most neurodegenerative diseases and constitutes the molecular basis of prion formation …

Type 2 diabetes is a progressive disease characterised by islet amyloid deposits in the
majority of patients. Amyloid formation is considered a significant factor in deterioration of …

The insulin granule was previously thought of as merely a container, but accumulating
evidence suggests that it also acts as a signaling node. Regulatory pathways intersect at but …

Cathelicidins are antimicrobial peptides produced by humans and animals in response to
various pathogenic microbes. This review intends to provide a brief overview of the …

Islet amyloid polypeptide (IAPP) is responsible for amyloid formation in type 2 diabetes and
contributes to the failure of islet cell transplants, however the mechanisms of IAPP-induced …