Multilayered Immunity by Tissue-Resident Lymphocytes in Cancer
Lymphocytes spanning the entire innate-adaptive spectrum can stably reside in tissues and
constitute an integral component of the local defense network against immunological …
constitute an integral component of the local defense network against immunological …
Co-expression of HLA-E and HLA-G on genetically modified porcine endothelial cells attenuates human NK cell-mediated degranulation
AA Cross-Najafi, K Farag, A Isidan, W Li… - Frontiers in …, 2023 - frontiersin.org
Natural killer (NK) cells play an important role in immune rejection in solid organ
transplantation. To mitigate human NK cell activation in xenotransplantation, introducing …
transplantation. To mitigate human NK cell activation in xenotransplantation, introducing …
HCMV-secreted glycoprotein gpUL4 inhibits TRAIL-mediated apoptosis and NK cell activation
VM Vlachava, S Seirafian, CA Fielding… - Proceedings of the …, 2023 - National Acad Sciences
Human cytomegalovirus (HCMV) is a paradigm of pathogen immune evasion and sustains
lifelong persistent infection in the face of exceptionally powerful host immune responses …
lifelong persistent infection in the face of exceptionally powerful host immune responses …
TRAIL-dependent apoptosis of peritoneal mesothelial cells by NK cells promotes ovarian cancer invasion
AM Steitz, C Schröder, I Knuth, CU Keber… - Iscience, 2023 - cell.com
A crucial requirement for metastasis formation in ovarian high-grade serous carcinoma
(HGSC) is the disruption of the protective peritoneal mesothelium. Using co-culture systems …
(HGSC) is the disruption of the protective peritoneal mesothelium. Using co-culture systems …
Hepatitis D infection induces IFN-β-mediated NK cell activation and TRAIL-dependent cytotoxicity
C Groth, J Maric, I Garcés Lázaro, T Hofman… - Frontiers in …, 2023 - frontiersin.org
Background and aims The co-infection of hepatitis B (HBV) patients with the hepatitis D virus
(HDV) causes the most severe form of viral hepatitis and thus drastically worsens the course …
(HDV) causes the most severe form of viral hepatitis and thus drastically worsens the course …
XPO1 inhibition sensitises CLL cells to NK cell mediated cytotoxicity and overcomes HLA-E expression
JG Fisher, ADP Doyle, LV Graham, S Sonar, B Sale… - Leukemia, 2023 - nature.com
The first-in-class inhibitor of exportin-1 (XPO1) selinexor is currently under clinical
investigation in combination with the BTK inhibitor ibrutinib for patients with chronic …
investigation in combination with the BTK inhibitor ibrutinib for patients with chronic …
Natural killer cells immunosenescence and the impact of lifestyle management
L Wang, L Mao, W Xiao, P Chen - Biochemical and Biophysical Research …, 2023 - Elsevier
Natural killer cells (NKs) are lymphocytes of the innate immune system that quickly respond
to viruses, infections, and tumors during their short cell life cycle. However, it was recently …
to viruses, infections, and tumors during their short cell life cycle. However, it was recently …
Early TRAIL-engagement elicits potent multimodal targeting of melanoma by CD34+ progenitor cell-derived NK cells
AA van Vliet, E Peters, D Vodegel, D Steenmans… - Iscience, 2023 - cell.com
Umbilical cord blood (UCB) CD34+ progenitor cell-derived natural killer (NK) cells exert
efficient cytotoxicity against various melanoma cell lines. Of interest, the relative cytotoxic …
efficient cytotoxicity against various melanoma cell lines. Of interest, the relative cytotoxic …
Digital spatial profiling of human parathyroid tumors reveals cellular and molecular alterations linked to vitamin D deficiency
CL Tu, W Chang, JA Sosa, J Koh - PNAS nexus, 2023 - academic.oup.com
Primary hyperparathyroidism (PHPT) is a common endocrine neoplastic disorder
characterized by disrupted calcium homeostasis secondary to inappropriately elevated …
characterized by disrupted calcium homeostasis secondary to inappropriately elevated …
iPSC‐derived NK cells with site‐specific integration of CAR19 and IL24 at the multi‐copy rDNA locus enhanced antitumor activity and proliferation
Y Zhang, Q Shi, P Wang, C Huang, S Tang… - MedComm, 2024 - Wiley Online Library
The generation of chimeric antigen receptor‐modified natural killer (CAR‐NK) cells using
induced pluripotent stem cells (iPSCs) has emerged as one of the paradigms for …
induced pluripotent stem cells (iPSCs) has emerged as one of the paradigms for …