The oral administration of therapeutic peptides and proteins is favoured from a patient and
commercial point of view. In order to reach the systemic circulation after oral administration …

As food transits the gastrointestinal tract, food structures are disrupted and nutrients are
absorbed across the gut barrier. In the past decade, great efforts have focused on the …

Introduction The FDA approval of oral semaglutide for type 2 diabetes (2019) and oral
octreotide for acromegaly (2020) is evidence that selected niche peptides can be …

Buccal delivery of small and large molecules is an attractive route of administration that has
been studied extensively over the past few decades. This route bypasses first-pass …

Bile acids are amphipathic, detergent molecules. The detergent effects of di-α-hydroxy-bile
acids are relevant to several colonic diseases. The aims were to review the concentrations …

Diabetes mellitus is a metabolic endocrine disease characterized by chronic hyperglycemia
with disturbances in metabolic processes, such as those related to carbohydrates, fat, and …

The oral route is considered an attractive method for drug delivery, as it avoids the hepatic
and intestinal first-pass metabolism processes. Hyaluronic acid (HA) beneficial effects to the …

The decades-long effort to deliver peptide drugs orally has resulted in several clinically
successful formulations. These formulations are enabled by the inclusion of permeation …

Recombinant biological molecules are at the cutting-edge of biomedical research thanks to
the significant progress made in biotechnology and a better understanding of subcellular …

The greatest achievement in the advanced drug delivery field should be the optimization of
non-invasive formulations for the delivery of high molecular weight compounds. Peptides …