Bioactive metal-based nanomedicines for boosting anti-tumor immunity: Advance, challenge, and perspective

Z Pei, L Li, N Yang, S Sun, N Jiang, L Cheng - Coordination Chemistry …, 2024 - Elsevier
Metal, as an active participant in life activities, has always been at the forefront of research.
Recent studies have revealed the crucial role of metal ions in activating the anti-tumor …

Nanotechnology-based in situ cancer vaccines: Mechanisms, design, and recent advances

G Niu, H Wang, Y Zhai, B Zhou, Y Kang, Z Pei, X Ji - Nano Today, 2024 - Elsevier
In recent years, in situ cancer vaccines, as an emerging cancer immunotherapy strategy,
have garnered considerable attention. This review comprehensively discusses the research …

Precisely activating cGAS‐STING pathway with a novel peptide‐based nanoagonist to potentiate immune checkpoint blockade cancer immunotherapy

Y Xing, A Peng, J Yang, Z Cheng, Y Yue… - Advanced …, 2024 - Wiley Online Library
As an essential intracellular immune activation pathway, the cGAS‐STING pathway has
attracted broad attention in cancer treatment. However, low bioavailability, nonspecificity …

Metal coordination nanotheranostics mediated by nucleoside metabolic inhibitors potentiate STING pathway activation for cancer metalloimmunotherapy

L Yang, Y Wang, Y Song, Z Li, L Lei, H Li, B He… - Journal of Controlled …, 2024 - Elsevier
Activation of the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING)
pathway is an effective way to initiate an immune response against tumors, and the research …

Tumor-responsive covalent organic polymeric nanoparticles enhancing STING activation for cancer immunotherapy

S Liang, J Yao, D Liu, M Zhou, Y Cui, Z Wang - Chinese Chemical Letters, 2024 - Elsevier
The cyclic guanosine monophosphate-adenosine monophosphate synthase and the
stimulator of interferon genes (cGAS-STING) has emerged as a promising target for cancer …

Injectable and NIR-Responsive CDN-POM Hydrogels for Combined Non-Inflammatory Photo-immunotherapy

H Jiang, D Liu, J Wang, J Li, X Pang, K Zhang, H Shan - 2024 - researchsquare.com
Similar to clinically applied thermal ablation techniques, the cellular necrosis that occurs
during photothermal tumor therapy (PTT) can induce inflammatory response, severely …