[HTML][HTML] Mitochondrial dysfunction and oxidative stress in Alzheimer's disease
A Misrani, S Tabassum, L Yang - Frontiers in aging neuroscience, 2021 - frontiersin.org
Mitochondria play a pivotal role in bioenergetics and respiratory functions, which are
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …
essential for the numerous biochemical processes underpinning cell viability. Mitochondrial …
Molecular mechanisms of TDP-43 misfolding and pathology in amyotrophic lateral sclerosis
A Prasad, V Bharathi, V Sivalingam… - Frontiers in molecular …, 2019 - frontiersin.org
TAR DNA binding protein 43 (TDP-43) is a versatile RNA/DNA binding protein involved in
RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as …
RNA-related metabolism. Hyper-phosphorylated and ubiquitinated TDP-43 deposits act as …
PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson's disease
That certain cell types in the central nervous system are more likely to undergo
neurodegeneration in Parkinson's disease is a widely appreciated but poorly understood …
neurodegeneration in Parkinson's disease is a widely appreciated but poorly understood …
[HTML][HTML] Hypoxia and brain aging: Neurodegeneration or neuroprotection?
The absolute reliance of the mammalian brain on oxygen to generate ATP renders it acutely
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …
vulnerable to hypoxia, whether at high altitude or in clinical settings of anemia or pulmonary …
[HTML][HTML] Mitophagy pathways in health and disease
SA Killackey, DJ Philpott, SE Girardin - The Journal of cell biology, 2020 - ncbi.nlm.nih.gov
Mitophagy is an evolutionarily conserved process involving the autophagic targeting and
clearance of mitochondria destined for removal. Recent insights into the complex nature of …
clearance of mitochondria destined for removal. Recent insights into the complex nature of …
Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: an update on current advances and …
Neurodegenerative diseases (NDs) such as Alzheimer disease (AD), Parkinson disease
(PD), and Huntington disease (HD) represent a major socio-economic challenge in view of …
(PD), and Huntington disease (HD) represent a major socio-economic challenge in view of …
[HTML][HTML] Dietary spermidine improves cognitive function
Decreased cognitive performance is a hallmark of brain aging, but the underlying
mechanisms and potential therapeutic avenues remain poorly understood. Recent studies …
mechanisms and potential therapeutic avenues remain poorly understood. Recent studies …
Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease
M Perluigi, F Di Domenico… - Physiological …, 2024 - journals.physiology.org
Alzheimer disease (AD) is associated with multiple etiologies and pathological mechanisms,
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
among which oxidative stress (OS) appears as a major determinant. Intriguingly, OS arises …
Metabolic dysregulation contributes to the progression of Alzheimer's disease
X Yan, Y Hu, B Wang, S Wang, X Zhang - Frontiers in neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) is an incurable neurodegenerative disease. Numerous studies
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …
ABCA7 deficiency causes neuronal dysregulation by altering mitochondrial lipid metabolism
K Kawatani, ML Holm, SC Starling, YA Martens… - Molecular …, 2024 - nature.com
ABCA7 loss-of-function variants are associated with increased risk of Alzheimer's disease
(AD). Using ABCA7 knockout human iPSC models generated with CRISPR/Cas9, we …
(AD). Using ABCA7 knockout human iPSC models generated with CRISPR/Cas9, we …