Aging is associated with progressive changes in total and regional fat distribution that have
negative health consequences. Indeed, a preferential increase in abdominal fat, in particular …

Lipids as fuel for energy provision originate from different sources: albumin-bound long-
chain fatty acids (LCFA) in the blood plasma, circulating very-low-density lipoproteins …

OBJECTIVE Age-associated insulin resistance may underlie the higher prevalence of type 2
diabetes in older adults. We examined a corollary hypothesis that obesity and level of …

An increased intramyocellular lipid (IMCL) content, as quantified by 1H-magnetic resonance
spectroscopy (1H-MRS), is associated with reduced insulin sensitivity. At present, it is …

Background: High fructose consumption is suspected to be causally linked to the epidemics
of obesity and metabolic disorders. In rodents, fructose leads to insulin resistance and …

Both stable isotope methodology and fluorescence microscopy were applied to define the
use of intramuscular triglyceride (IMTG) stores as a substrate source during exercise on a …

Purpose The purpose of this study was to assess relationships between intramuscular
adipose tissue (IntraMAT) content determined by MRI and intramyocellular lipids (IMCL) and …

In recent decades, metabolic syndrome has become a public health problem throughout the
world. Longitudinal studies in humans have several limitations due to the invasive nature of …

Numerous studies have reported a strong correlation between intramuscular triacylglycerol
(IMTG) content and insulin resistance. However, the proposed relationship between IMTG …

Fat and carbohydrate are the principal substrates that fuel aerobic ATP synthesis in skeletal
muscle. Most endogenous fat is stored as triacylglycerol in subcutaneous and deep visceral …