The hierarchical framework of the adult blood system as we know it from current medical and
hematology textbooks, displays a linear branching network of dividing and differentiated …

Abstract Background Type 1 diabetes (T1D) is an autoimmune disease characterized by
impaired immune tolerance to β-cell antigens and progressive destruction of insulin …

Hematopoietic stem cells (HSCs) are the rare cells responsible for the lifelong curative
effects of hematopoietic cell (HC) transplantation. The demand for clinical-grade HSCs has …

The ability to manufacture human hematopoietic stem cells (HSCs) in the laboratory holds
enormous promise for cellular therapy of human blood diseases. Several differentiation …

Human pluripotent stem cells (hPSCs) have been suggested as a potential source for the
production of blood cells for clinical application. In two decades, almost all types of blood …

Microgravity has been shown to induces many changes in proliferation, differentiation and
growth behavior of stem cells. Little is known about the effect of microgravity on …

Advances in modern medicine have enabled a rapid increase in lifespan and, consequently,
have highlighted the immune system as a key driver of age-related disease. Immune …

Hemogenic endothelium (HE) with hematopoietic stem cell (HSC)-forming potential emerge
from specialized arterial endothelial cells (AECs) undergoing the endothelial-to …

Familial platelet disorder with associated myeloid malignancies (FPDMM) is an autosomal
dominant disease caused by heterozygous germline mutations in RUNX1. It is characterized …

Background: To improve the efficiency of neural development from human embryonic stem
cells, human embryoid body (hEB) generation is vital through 3-dimensional formation …