Apoptosis has long been recognized as a mechanism that kills the cancer cells by cytotoxic
drugs. In recent years, studies have proved that pyroptosis can also shrink tumors and inhibit …

Pyroptosis, a form of programmed cell death, has garnered increasing attention as it relates
to innate immunity and diseases. The discovery of caspase-1/3/4/5/8/11 function in sensing …

Pyroptosis is a gasdermins mediated programmed cell death, which has been widely
studied in inflammatory disease models. Recently, there are growing evidences that …

BRD4 has long been implicated in many different pathological processes, in particular, the
development of cancer and inflammation. Pyroptosis is a newly recognized type of …

There has been increasing interest in pyroptosis as a novel form of pro-inflammatory
programmed cell death. The mechanism of pyroptosis is significantly different from other …

Rationale: Malignant ascites caused by cancer cells results in poor prognosis and short
average survival time. No effective treatment is currently available for malignant ascites. In …

Scavenging reactive oxygen species (ROS) by antioxidants is the important therapy to
cerebral ischemia-reperfusion injury (CIRI) in stroke. The antioxidant with novel dual …

Pyroptosis is mainly considered a gasdermin-regulated cell death mechanism characterized
by cellular lysis and the release of several pro-inflammatory factors. Nowadays, pyroptosis …

The present study established thirteen novel 8-hydroxyquinoline/chalcone hybrids 3a–m of
hopeful anticancer activity. According to NCI screening and MTT assay results, compounds …

Tumor resistance to apoptosis and the immunosuppressive tumor microenvironment are two
main reasons for the poor outcomes of tumor treatment. Pyroptosis is a newly discovered …