Abstract Treatment outcomes for major depressive disorder (MDD) need to be improved.
Presently, no clinically relevant tools have been established for stratifying subgroups or …

Objectives: To provide guidance for the management of mood disorders, based on scientific
evidence supplemented by expert clinical consensus and formulate recommendations to …

The issue of the severity of psychiatric disorders has great clinical importance. For example,
severity influences decisions about level of care, and affects decisions to seek government …

Background In recent years, we have accomplished a deeper understanding about the
pathophysiology of major depressive disorder (MDD). Nevertheless, this improved …

Major depressive disorder (MDD) is a prevalent psychiatric disorder associated with varied
prognosis, chronic course, and duration of illness with reduced quality of life. One factor that …

Background Childhood trauma is a common and potent risk factor for developing major
depressive disorder in adulthood, associated with earlier onset, more chronic or recurrent …

Objective: The present study examined the efficacy, safety, and durability of repeated
ketamine infusions for the treatment of comorbid posttraumatic stress disorder (PTSD) and …

Background Anhedonia, or diminished interest or pleasure in rewarding activities,
characterizes depression and reflects deficits in brain reward circuitries. Social stress …

There have been significant advancements in the pharmacologic management of
posttraumatic stress disorder (PTSD) in the past two decades. Multisite randomized clinical …

Major depressive disorder (MDD) is a chronic condition that affects one in six adults in the
US during their lifetime. The current practice of antidepressant medication prescription is a …