Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …

Women are at twice the risk for anxiety and depression disorders as men are, although the
underlying biological factors and mechanisms are largely unknown. In this review, we …

Psychedelics are a broad class of drugs defined by their ability to induce an altered state of
consciousness,. These drugs have been used for millennia in both spiritual and medicinal …

The emerging therapeutic efficacy of ketamine and classical psychedelics for depression
has inspired tremendous interest in the underlying neurobiological mechanisms. We review …

Abstract (R, S)-ketamine elicits rapid-acting and sustained antidepressant actions in
treatment-resistant patients with depression.(R)-ketamine produces longer-lasting …

The brain-derived neurotrophic factor (BDNF) has received considerable attention as a
potential biomarker of major depressive disorder (MDD) and antidepressant response. We …

In addition to producing profound subjective effects following acute administration,
psychedelic compounds can induce beneficial behavioral changes relevant to the treatment …

Psychedelics make up a group of psychoactive compounds that induce hallucinogenic
effects by activating the serotonin 2A receptor (5-HT2AR). Clinical trials have demonstrated …

Psychedelic compounds have displayed antidepressant potential in both humans and
rodents. Despite their promise, psychedelics can induce undesired effects that pose safety …

Ketamine exhibits rapid and sustained antidepressant effects. As decreased myelination has
been linked to depression pathology, changes in myelination may be a pivotal mechanism …