Carotenoids are natural fat-soluble pigments that provide bright coloration to plants and
animals. Dietary intake of carotenoids is inversely associated with the risk of a variety of …

Metabolic syndrome is estimated to affect more than one in five adults, and its prevalence is
growing in the adult and pediatric populations. The most widely recognized metabolic risk …

We review the rationale for the use of synthetic oleanane triterpenoids (SOs) for prevention
and treatment of disease, as well as extensive biological data on this topic resulting from …

Asthma is a chronic disease of the airways that has long been viewed predominately as an
inflammatory condition. Accordingly, current therapeutic interventions focus primarily on …

Inflammation is a beneficial host reaction to tissue damage and has the essential primary
purpose of restoring tissue homeostasis. Inflammation plays a major role in containing and …

Endothelial cells exert an enormous influence on blood vessels throughout the circulation,
but their impact is particularly pronounced in the brain. New concepts have emerged …

The Gadd45 proteins have been intensively studied, in view of their important role in key
cellular processes. Indeed, the Gadd45 proteins stand at the crossroad of the cell fates by …

Gastric cancer (GC) is a lethal malignancy and the second most common cause of cancer-
related deaths. Although treatment options such as chemotherapy, radiotherapy, and …

MitoNEET (mNT) is an outer mitochondrial membrane target of the thiazolidinedione
diabetes drugs with a unique fold and a labile [2Fe-2S] cluster. The rare 1-His and 3-Cys …

Macrophages, which have various phenotypes and diverse functions, are becoming the
target cells in inflammatory diseases. In this study, we evaluated the effects of the natural …