Background: Cholinesterase (ChE) inhibitors currently used in the treatment of Alzheimer's
disease (AD) are the acetylcholinesterase (AChE)-selective inhibitors, donepezil and …

The deficiency in cholinergic neurotransmission in Alzheimer's disease has led to the
development of cholinesterase inhibitors as the first-line treatment for symptoms of this …

Alzheimer's disease (AD) is an age-related neurodegenerative disease that affects
approximately 4.5 million people in the United States. The mainstays of current …

The most important therapeutic effect of cholinesterase inhibitors (ChEI) on approximately
50% of Alzheimer's disease (AD) patients is to stabilize cognitive function at a steady level …

Among the various drug discovery methods, a very promising modern approach consists in
designing multi-target-directed ligands (MTDLs). This methodology has been specifically …

With the aging population and its rapidly increasing prevalence, dementia has become an
important public health concern in developed and developing countries. To date, the …

Structure-based virtual screening of two libraries containing 567 981 molecules was used to
discover novel, selective BuChE inhibitors, which are potentially superior symptomatic …

The increasing life expectancy in our population makes Alzheimer's disease (AD) a growing
public health problem. There is a great need to find a way to prevent and delay the disease …

S. fruticosa and S. officinalis var. purpurea was evident. IC50 values decreased from
0.15±0.007 and 0.14±0.007 mg/mL after 5 min to 0.035±0.016 and 0.06±0.018 mg/mL after …

Organophosphorus (OP) nerve agents and pesticides present significant threats to civilian
and military populations. OP compounds include the nefarious G and V chemical nerve …