A comprehensive review of multi-target directed ligands in the treatment of Alzheimer's disease

C Pathak, UD Kabra - Bioorganic Chemistry, 2024 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia affecting specifically older
population. AD is an irreversible neurodegenerative CNS disorder associated with complex …

Recent developments in cholinesterases inhibitors for Alzheimer's disease treatment

A Musial, M Bajda, B Malawska - Current medicinal chemistry, 2007 - ingentaconnect.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the central
nervous system (CNS) which is the most common cause of dementia in the elderly. It is …

Synthesis, characterization, molecular docking, and biological activities of coumarin–1, 2, 3‐triazole‐acetamide hybrid derivatives

N Sepehri, M Mohammadi‐Khanaposhtani… - Archiv der …, 2020 - Wiley Online Library
Coumarins and their derivatives are receiving increasing attention due to numerous
biochemical and pharmacological applications. In this study, a series of novel coumarin–1 …

Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease

A Hostalkova, J Marikova, L Opletal… - Journal of natural …, 2019 - ACS Publications
Three new alkaloids, bersavine (3), muraricine (4), and berbostrejdine (8), together with
seven known isoquinoline alkaloids (1–2, 5–7, 9, and 10) were isolated from an alkaloidal …

Galantamine hydrobromide: an agent for Alzheimer's disease

V Zarotsky, JJ Sramek, NR Cutler - American journal of health …, 2003 - academic.oup.com
The pharmacology, dosage, adverse effects, efficacy, and economics of galantamine
hydrobromide are discussed. Galantamine hydrobromide is a tertiary alkaloid that has been …

[HTML][HTML] Cholinergic treatments with emphasis on m1 muscarinic agonists as potential disease-modifying agents for Alzheimer's disease

A Fisher - Neurotherapeutics, 2008 - Elsevier
The only prescribed drugs for treatment of Alzheimer's disease (AD) are
acetylcholinesterase inhibitors (eg, donepezil, rivastigmine, galantamine, and tacrine) and …

Inhibition of human cholinesterases by drugs used to treat Alzheimer disease

S Darvesh, R Walsh, R Kumar, A Caines… - Alzheimer Disease & …, 2003 - journals.lww.com
Current approaches to the treatment of cognitive and behavioral symptoms of Alzheimer
disease emphasize the use of cholinesterase inhibitors. The kinetic effects of the …

Identification of compounds for butyrylcholinesterase inhibition

S Li, AJ Li, J Travers, T Xu… - … the Science of Drug …, 2021 - journals.sagepub.com
Butyrylcholinesterase (BChE) is a nonspecific cholinesterase enzyme that hydrolyzes
choline-based esters. BChE plays a critical role in maintaining normal cholinergic function …

Multitarget strategies in Alzheimer's disease: benefits and challenges on the road to therapeutics

M Rosini, E Simoni, R Caporaso… - Future medicinal …, 2016 - Taylor & Francis
Alzheimer's disease is a multifactorial syndrome, for which effective cures are urgently
needed. Seeking for enhanced therapeutic efficacy, multitarget drugs have been …

Pathogenesis of Alzheimer's Disease and Diversity of 1, 2, 3-Triazole Scaffold in Drug Development: Design Strategies, Structural Insights, and Therapeutic Potential

A Singh, K Singh, J Kaur, R Kaur… - ACS chemical …, 2023 - ACS Publications
Alzheimer's disease is a most prevalent form of dementia all around the globe and currently
poses a significant challenge to the healthcare system. Currently available drugs only slow …