A comprehensive review of multi-target directed ligands in the treatment of Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia affecting specifically older
population. AD is an irreversible neurodegenerative CNS disorder associated with complex …
population. AD is an irreversible neurodegenerative CNS disorder associated with complex …
Recent developments in cholinesterases inhibitors for Alzheimer's disease treatment
A Musial, M Bajda, B Malawska - Current medicinal chemistry, 2007 - ingentaconnect.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder of the central
nervous system (CNS) which is the most common cause of dementia in the elderly. It is …
nervous system (CNS) which is the most common cause of dementia in the elderly. It is …
Synthesis, characterization, molecular docking, and biological activities of coumarin–1, 2, 3‐triazole‐acetamide hybrid derivatives
N Sepehri, M Mohammadi‐Khanaposhtani… - Archiv der …, 2020 - Wiley Online Library
Coumarins and their derivatives are receiving increasing attention due to numerous
biochemical and pharmacological applications. In this study, a series of novel coumarin–1 …
biochemical and pharmacological applications. In this study, a series of novel coumarin–1 …
Isoquinoline Alkaloids from Berberis vulgaris as Potential Lead Compounds for the Treatment of Alzheimer's Disease
A Hostalkova, J Marikova, L Opletal… - Journal of natural …, 2019 - ACS Publications
Three new alkaloids, bersavine (3), muraricine (4), and berbostrejdine (8), together with
seven known isoquinoline alkaloids (1–2, 5–7, 9, and 10) were isolated from an alkaloidal …
seven known isoquinoline alkaloids (1–2, 5–7, 9, and 10) were isolated from an alkaloidal …
Galantamine hydrobromide: an agent for Alzheimer's disease
V Zarotsky, JJ Sramek, NR Cutler - American journal of health …, 2003 - academic.oup.com
The pharmacology, dosage, adverse effects, efficacy, and economics of galantamine
hydrobromide are discussed. Galantamine hydrobromide is a tertiary alkaloid that has been …
hydrobromide are discussed. Galantamine hydrobromide is a tertiary alkaloid that has been …
[HTML][HTML] Cholinergic treatments with emphasis on m1 muscarinic agonists as potential disease-modifying agents for Alzheimer's disease
A Fisher - Neurotherapeutics, 2008 - Elsevier
The only prescribed drugs for treatment of Alzheimer's disease (AD) are
acetylcholinesterase inhibitors (eg, donepezil, rivastigmine, galantamine, and tacrine) and …
acetylcholinesterase inhibitors (eg, donepezil, rivastigmine, galantamine, and tacrine) and …
Inhibition of human cholinesterases by drugs used to treat Alzheimer disease
Current approaches to the treatment of cognitive and behavioral symptoms of Alzheimer
disease emphasize the use of cholinesterase inhibitors. The kinetic effects of the …
disease emphasize the use of cholinesterase inhibitors. The kinetic effects of the …
Identification of compounds for butyrylcholinesterase inhibition
Butyrylcholinesterase (BChE) is a nonspecific cholinesterase enzyme that hydrolyzes
choline-based esters. BChE plays a critical role in maintaining normal cholinergic function …
choline-based esters. BChE plays a critical role in maintaining normal cholinergic function …
Multitarget strategies in Alzheimer's disease: benefits and challenges on the road to therapeutics
M Rosini, E Simoni, R Caporaso… - Future medicinal …, 2016 - Taylor & Francis
Alzheimer's disease is a multifactorial syndrome, for which effective cures are urgently
needed. Seeking for enhanced therapeutic efficacy, multitarget drugs have been …
needed. Seeking for enhanced therapeutic efficacy, multitarget drugs have been …
Pathogenesis of Alzheimer's Disease and Diversity of 1, 2, 3-Triazole Scaffold in Drug Development: Design Strategies, Structural Insights, and Therapeutic Potential
Alzheimer's disease is a most prevalent form of dementia all around the globe and currently
poses a significant challenge to the healthcare system. Currently available drugs only slow …
poses a significant challenge to the healthcare system. Currently available drugs only slow …