In silico design of dual-binding site anti-cholinesterase phytochemical heterodimers as treatment options for Alzheimer's disease
The number of patients with neurodegenerative diseases, particularly Alzheimer's disease
(AD), continues to grow yearly. Cholinesterase inhibitors (ChEIs) represent the first-line …
(AD), continues to grow yearly. Cholinesterase inhibitors (ChEIs) represent the first-line …
Quinolizidinyl derivatives of bi-and tricyclic systems as potent inhibitors of acetyl-and butyrylcholinesterase with potential in Alzheimer's disease
On the pattern of the potent and selective butyrylcholinesterase (BChE) inhibitors
ethopropazine and Astra1397, sets of quinolizidinyl derivatives of bi-and tricyclic (hetero) …
ethopropazine and Astra1397, sets of quinolizidinyl derivatives of bi-and tricyclic (hetero) …
Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile
K Sobolova, M Hrabinova, V Hepnarova… - European journal of …, 2020 - Elsevier
Berberine, a naturally occurring compound, possesses an interesting multipotent
pharmacological profile potentially applicable for Alzheimer's disease (AD) treatment. In this …
pharmacological profile potentially applicable for Alzheimer's disease (AD) treatment. In this …
The path from anti Parkinson drug selegiline and rasagiline to multifunctional neuroprotective anti Alzheimer drugs ladostigil and m30
MBH Youdim - Current Alzheimer Research, 2006 - ingentaconnect.com
The therapeutic use of enzyme inhibitors in treatment of neurodegenerative diseases has its
origin in the anti Parkinson action of the selective monoamine oxidase (MAO) B inhibitor, l …
origin in the anti Parkinson action of the selective monoamine oxidase (MAO) B inhibitor, l …
Chromone derivatives bearing pyridinium moiety as multi-target-directed ligands against Alzheimer's disease
A new serise of 7-hydroxy-chromone derivatives bearing pyridine moiety were synthesized,
and evaluated as multifunctional agents against Alzheimer's disease (AD). Most of the …
and evaluated as multifunctional agents against Alzheimer's disease (AD). Most of the …
Cholinesterase-based biosensors
Š Štěpánková, K Vorčáková - Journal of enzyme inhibition and …, 2016 - Taylor & Francis
Recently, cholinesterase-based biosensors are widely used for assaying anticholinergic
compounds. Primarily biosensors based on enzyme inhibition are useful analytical tools for …
compounds. Primarily biosensors based on enzyme inhibition are useful analytical tools for …
Multitarget Therapeutic Leads for Alzheimer's Disease: Quinolizidinyl Derivatives of Bi‐and Tricyclic Systems as Dual Inhibitors of Cholinesterases and β‐Amyloid (Aβ) …
Multitarget therapeutic leads for Alzheimer's disease were designed on the models of
compounds capable of maintaining or restoring cell protein homeostasis and of inhibiting β …
compounds capable of maintaining or restoring cell protein homeostasis and of inhibiting β …
The impact of Aβ-plaques on cortical cholinergic and non-cholinergic presynaptic boutons in Alzheimer's disease-like transgenic mice
A previous study in our laboratory, involving early stage, amyloid pathology in 8-month-old
transgenic mice, demonstrated a selective loss of cholinergic terminals in the cerebral and …
transgenic mice, demonstrated a selective loss of cholinergic terminals in the cerebral and …
Structural aspects of 4-aminoquinolines as reversible inhibitors of human acetylcholinesterase and butyrylcholinesterase
Eight derivatives of 4-aminoquinolines differing in the substituents attached to the C (4)-
amino group and C (7) were synthesised and tested as inhibitors of human …
amino group and C (7) were synthesised and tested as inhibitors of human …
A novel cholinesterase and brain-selective monoamine oxidase inhibitor for the treatment of dementia comorbid with depression and Parkinson's disease
M Weinstock, E Gorodetsky, T Poltyrev, A Gross… - Progress in Neuro …, 2003 - Elsevier
Degeneration of cholinergic cortical neurons is one of the main reasons for the cognitive
deficit in dementia of the Alzheimer type (AD) and in dementia with Lewy bodies (DLB) …
deficit in dementia of the Alzheimer type (AD) and in dementia with Lewy bodies (DLB) …