[PDF][PDF] State of the science on brain insulin resistance and cognitive decline due to Alzheimer's disease
Type 2 diabetes mellitus (T2DM) is common and increasing in prevalence worldwide, with
devastating public health consequences. While peripheral insulin resistance is a key feature …
devastating public health consequences. While peripheral insulin resistance is a key feature …
[HTML][HTML] Metabolic diffusion in Neuropathologies: the relevance of Brain-Liver Axis
S Vegas-Suárez, J Simón, ML Martínez-Chantar… - Frontiers in …, 2022 - frontiersin.org
Chronic liver diseases include a broad group of hepatic disorders from different etiologies
and with varying degrees of progression and severity. Among them, non-alcoholic fatty …
and with varying degrees of progression and severity. Among them, non-alcoholic fatty …
Cerebrovascular insulin receptors are defective in Alzheimer's disease
M Leclerc, P Bourassa, C Tremblay, V Caron, C Sugère… - Brain, 2023 - academic.oup.com
Central response to insulin is suspected to be defective in Alzheimer's disease. As most
insulin is secreted in the bloodstream by the pancreas, its capacity to regulate brain …
insulin is secreted in the bloodstream by the pancreas, its capacity to regulate brain …
Sulforaphane protects against unilateral ureteral obstruction-induced renal damage in rats by alleviating mitochondrial and lipid metabolism impairment
Unilateral ureteral obstruction (UUO) is an animal rodent model that allows the study of
obstructive nephropathy in an accelerated manner. During UUO, tubular damage is induced …
obstructive nephropathy in an accelerated manner. During UUO, tubular damage is induced …
Curcumin Mitigates the High-Fat High-Sugar Diet-Induced Impairment of Spatial Memory, Hepatic Metabolism, and the Alteration of the Gut Microbiome in Alzheimer's …
The escalating prevalence of metabolic diseases and an aging demographic has been
correlated with a concerning rise in Alzheimer's disease (AD) incidence. This study aimed to …
correlated with a concerning rise in Alzheimer's disease (AD) incidence. This study aimed to …
[HTML][HTML] Combined metabolic activators improve metabolic functions in the animal models of neurodegenerative diseases
Abstract Background Neurodegenerative diseases (NDDs), including Alzheimer's disease
(AD) and Parkinson's disease (PD), are associated with metabolic abnormalities. Integrative …
(AD) and Parkinson's disease (PD), are associated with metabolic abnormalities. Integrative …
Environmental Microcystin exposure in underlying NAFLD-induced exacerbation of neuroinflammation, blood-brain barrier dysfunction, and neurodegeneration are …
Nonalcoholic fatty liver disease (NAFLD) has been shown to be associated with extrahepatic
comorbidities including neuronal inflammation and Alzheimer's-like pathology …
comorbidities including neuronal inflammation and Alzheimer's-like pathology …
Peripheral metabolism of lipoprotein-amyloid beta as a risk factor for Alzheimer's disease: potential interactive effects of APOE genotype with dietary fats
ZJ D'Alonzo, V Lam, R Takechi, M Nesbit… - Genes & Nutrition, 2023 - Springer
Alzheimer's disease (AD) is a progressive neurodegenerative disorder pathologically
characterized by brain parenchymal abundance of amyloid-beta (Aβ) and the accumulation …
characterized by brain parenchymal abundance of amyloid-beta (Aβ) and the accumulation …
Hepatopancreatic metabolic disorders and their implications in the development of Alzheimer's disease and vascular dementia
FI Pinheiro, I Araújo-Filho, ACM do Rego… - Ageing Research …, 2024 - Elsevier
Dementia has been faced with significant public health challenges and economic burdens
that urges the need to develop safe and effective interventions. In recent years, an …
that urges the need to develop safe and effective interventions. In recent years, an …
Olive-and coconut-oil-enriched diets decreased secondary bile acids and regulated metabolic and transcriptomic markers of brain injury in the frontal cortexes of …
MA Maj, TR Gehani, C Immoos, MS Medrano… - Brain sciences, 2022 - mdpi.com
The objective of this study was to investigate the effect of dietary fatty acid (FA) saturation
and carbon chain length on brain bile acid (BA) metabolism and neuronal number in a pig …
and carbon chain length on brain bile acid (BA) metabolism and neuronal number in a pig …