Histone modifying enzymes play critical roles in many key cellular processes and are
appealing proteins for targeting by small molecules in disease. However, while the functions …

Epigenetic dysregulation is an important contributor to carcinogenesis. This is not surprising,
as chromatin—genomic DNA organized around structural histone scaffolding—serves as the …

RNA binding motif protein 15 (RBM15) is a key regulatory factor involved in N6-
methyladenosine (m6A) methylation. It has been reported that RBM15 plays an important …

Background Clear cell renal cell carcinoma (ccRCC) is a prevalent urological malignancy
associated with a high mortality rate. The lack of a reliable prognostic biomarker undermines …

Purpose: Chordoma is a rare bone tumor with a high recurrence rate and limited treatment
options. The aim of this study was to identify molecular subtypes of chordoma that may …

Background RAD51, a critical protein for DNA repairment, has been found to associate with
multiple cancer types, but, so far, a systematic pan-cancer analysis of RAD51 has not been …

Minichromosome maintenance 2 (MCM2) is a member of the minichromosomal
maintenance family of proteins that mainly regulates DNA replication and the cell cycle and …

Background Latest guidelines recommended immunotherapy (IO) plus tyrosine kinase
inhibitor (TKI) combination as standard first-line therapy in renal cell carcinoma (RCC), with …

Abstract Background Solute Carrier Family 31 Member 1 (SLC31A1) has recently been
identified as a cuproptosis-regulatory gene. Recent studies have indicated that SLC31A1 …

Epigenetic regulation plays an important role in the occurrence, development and treatment
of tumors. The histone methyltransferase SET-domain-containing 2 (SETD2) plays a key role …