Objective: Psychiatric symptoms are a significant aspect of Huntington's disease, an
inherited neurodegenerative illness. The presentation of these symptoms is highly variable …

Huntington's disease (HD) is traditionally considered as a triad of movement, cognitive, and
emotional disorders. 1–4 According to current clinical practice,“manifest HD” is diagnosed …

Recent studies have identified impairments in neural induction and in striatal and cortical
neurogenesis in Huntington's disease (HD) knock-in mouse models and associated …

Established in July 2012, Enroll-HD is both an integrated clinical research platform and a
worldwide observational study designed to meet the clinical research requirements …

Synaptic dysfunction and altered calcium homeostasis in the brain is common to many
neurodegenerative disorders. Among these, Huntington disease (HD), which is inherited in …

Background Applying machine‐learning algorithms to large datasets such as those
available in Huntington's disease offers the opportunity to discover hidden patterns, often not …

Cognitive, motor and psychiatric changes in prodromal Huntington's disease have nurtured
the emergent need for early interventions. Preventive clinical trials for Huntington's disease …

Huntington disease (HD) is a dominantly inherited disorder caused by a CAG expansion
mutation in the huntingtin (HTT) gene, which results in the HTT protein that contains an …

Background Development of disease‐modifying treatments for Huntington's disease (HD)
could be aided by the use of imaging biomarkers of disease progression. Positron emission …

Learning and memory deficits are early clinical manifestations of Huntington's disease (HD).
These cognitive impairments have been mainly associated with frontostriatal HD pathology; …