The classical neural model of language refers to a cortical network involving frontal, parietal
and temporal regions. However, patients with subcortical lesions of the striatum have …

Objectives Diffusivity in white‐matter tracts is abnormal throughout the brain in cross‐
sectional studies of prodromal Huntington's disease. To date, longitudinal changes have not …

Huntington's disease (HD) is a fatal neurodegenerative disorder caused by an expansion of
the CAG repeats in the huntingtin gene (HTT). Although HD has been shown to have a …

Objectives: People with Huntington's disease (HD) experience poor social quality of life,
relationship breakdown, and social withdrawal, which are mediated to some extent by …

Despite its drawbacks, the complete case analysis is commonly used in regression models
with incomplete covariates. Understanding when the complete case analysis will lead to …

Background Despite the monogenic autosomal dominant nature of Huntington's disease
(HD), the current research paradigm is still based on overt clinical phenotypes and does not …

Objective Huntington's disease is a rare, genetic, neurodegenerative disease characterized
by a triad of cognitive, behavioral, and motor symptoms. The condition gradually results in …

Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder that
progressively affects motor, cognitive, and emotional functions. Structural MRI studies have …

Multicenter longitudinal neuroimaging has great potential to provide efficient and consistent
biomarkers for research of neurodegenerative diseases and aging. In rare disease studies it …

An abundance of research shows that magnetic resonance imaging (MRI) striatal volumes
decrease long before diagnosis of Huntington's disease (HD) and closely track disease …