[HTML][HTML] Interactions of IDO and the kynurenine pathway with cell transduction Systems and metabolism at the inflammation–cancer interface
TW Stone, RO Williams - Cancers, 2023 - mdpi.com
Simple Summary There is clear evidence that inflammation can contribute to the
development of cancers, but the underlying mechanisms are not fully understood. This …
development of cancers, but the underlying mechanisms are not fully understood. This …
[HTML][HTML] Glutaminolysis and CD4+ T-cell metabolism in autoimmunity: From pathogenesis to therapy prospects
X Feng, X Li, N Liu, N Hou, X Sun, Y Liu - Frontiers in Immunology, 2022 - frontiersin.org
The recent increase in the pathogenesis of autoimmune diseases revealed the critical role of
T cells. Investigation into immunometabolism has drawn attention to metabolic processes …
T cells. Investigation into immunometabolism has drawn attention to metabolic processes …
[HTML][HTML] Targeting glutamine metabolism in hepatic stellate cells alleviates liver fibrosis
X Yin, J Peng, L Gu, Y Liu, X Li, J Wu, B Xu… - Cell Death & …, 2022 - nature.com
Glutamine metabolism plays an essential role in cell growth, and glutamate dehydrogenase
(GDH) is a key enzyme. GDH promotes the metabolism of glutamate and glutamine to …
(GDH) is a key enzyme. GDH promotes the metabolism of glutamate and glutamine to …
[HTML][HTML] CD4+ T-cell subsets in autoimmune hepatitis: A review
H Chen, Z Han, Y Fan, L Chen, F Peng… - Hepatology …, 2023 - journals.lww.com
Autoimmune hepatitis (AIH) is a chronic autoimmune liver disease that can lead to
hepatocyte destruction, inflammation, liver fibrosis, cirrhosis, and liver failure. The diagnosis …
hepatocyte destruction, inflammation, liver fibrosis, cirrhosis, and liver failure. The diagnosis …
Umbilical Cord‐Derived Mesenchymal Stem Cells Attenuate S100‐Induced Autoimmune Hepatitis via Modulating Th1 and Th17 Cell Responses in Mice
X Wei, X Cheng, Y Luo, X Li - Stem Cells International, 2023 - Wiley Online Library
Currently, the first‐line treatment for autoimmune hepatitis (AIH) is still the combination of
glucocorticoids or immunosuppressants. However, hormone and immunosuppressive …
glucocorticoids or immunosuppressants. However, hormone and immunosuppressive …
[HTML][HTML] The role of amino acid metabolism in autoimmune hepatitis
X Xiang, Q Li, J Wan, C Chen, M Guo, Z He… - Biomedicine & …, 2024 - Elsevier
Autoimmune hepatitis (AIH) is an inflammatory chronic liver disease with persistent and
recurrent immune-mediated liver injury. The exact cause of AIH is still not fully understood …
recurrent immune-mediated liver injury. The exact cause of AIH is still not fully understood …
[HTML][HTML] Bioinformatics analysis of immune cell infiltration patterns and potential diagnostic markers in atherosclerosis
H Ji, L Yuan, W Jiang, Y Jiang, M Jiang, X Sun… - Scientific Reports, 2023 - nature.com
This study aimed to investigate efficient diagnostic markers and molecular mechanisms of
atherosclerosis and to analyze the role of immune infiltration through bioinformatics …
atherosclerosis and to analyze the role of immune infiltration through bioinformatics …
TPN10475 alleviates concanavalin A-induced autoimmune hepatitis by limiting T cell development and function through inhibition of PI3K-AKT pathway
C Wang, M Han, X Li, J Lv, W Zhuang, L Xie… - International …, 2023 - Elsevier
Autoimmune hepatitis (AIH) is an inflammatory liver disease in which the autoimmune
system instigates an attack on the liver, causing inflammation and liver injury, and its …
system instigates an attack on the liver, causing inflammation and liver injury, and its …
Glutaminolysis of CD4+ T Cells: A Potential Therapeutic Target in Viral Diseases
Y Xu, M Li, M Lin, D Cui, J Xie - Journal of Inflammation Research, 2024 - Taylor & Francis
CD4+ T cells play a critical role in the pathogenesis of viral diseases, which are activated by
the internal metabolic pathways encountering with viral antigens. Glutaminolysis converts …
the internal metabolic pathways encountering with viral antigens. Glutaminolysis converts …
Unlocking the potential of T‐cell metabolism reprogramming: Advancing single‐cell approaches for precision immunotherapy in tumour immunity
L Huang, H Li, C Zhang, Q Chen, Z Liu… - Clinical and …, 2024 - Wiley Online Library
As single‐cell RNA sequencing enables the detailed clustering of T‐cell subpopulations and
facilitates the analysis of T‐cell metabolic states and metabolite dynamics, it has gained …
facilitates the analysis of T‐cell metabolic states and metabolite dynamics, it has gained …