Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease

Q Yan, S Liu, Y Sun, C Chen, S Yang, M Lin… - Journal of Translational …, 2023 - Springer
Cardiovascular diseases (CVDs) continue to exert a significant impact on global mortality
rates, encompassing conditions like pulmonary arterial hypertension (PAH), atherosclerosis …

Mitochondrial homeostasis in VSMCs as a central hub in vascular remodeling

Y Xia, X Zhang, P An, J Luo, Y Luo - International journal of molecular …, 2023 - mdpi.com
Vascular remodeling is a common pathological hallmark of many cardiovascular diseases.
Vascular smooth muscle cells (VSMCs) are the predominant cell type lining the tunica media …

Accelerated discovery of superoxide-dismutase nanozymes via high-throughput computational screening

Z Wang, J Wu, JJ Zheng, X Shen, L Yan, H Wei… - Nature …, 2021 - nature.com
The activity of nanomaterials (NMs) in catalytically scavenging superoxide anions mimics
that of superoxide dismutase (SOD). Although dozens of NMs have been demonstrated to …

Uremic toxins and frailty in patients with chronic kidney disease: a molecular insight

CT Chao, SH Lin - International journal of molecular sciences, 2021 - mdpi.com
The accumulation of uremic toxins (UTs) is a prototypical manifestation of uremic milieu that
follows renal function decline (chronic kidney disease, CKD). Frailty as a potential outcome …

NIPSNAP1 directs dual mechanisms to restrain senescence in cancer cells

E Gao, X Sun, RF Thorne, XD Zhang, J Li… - Journal of Translational …, 2023 - Springer
Background Although the executive pathways of senescence are known, the underlying
control mechanisms are diverse and not fully understood, particularly how cancer cells avoid …

[HTML][HTML] Epigenetically regulated inflammation in vascular senescence and renal progression of chronic kidney disease

CT Chao, FC Kuo, SH Lin - Seminars in Cell & Developmental Biology, 2022 - Elsevier
Chronic kidney disease (CKD) and its complications, including vascular senescence and
progressive renal fibrosis, are associated with inflammation. Vascular senescence, in …

Gender-related differences in chronic kidney disease-associated vascular calcification risk and potential risk mediators: a scoping review

PY Wu, SY Lee, KV Chang, CT Chao, JW Huang - Healthcare, 2021 - mdpi.com
Vascular calcification (VC) involves the deposition of calcium apatite in vascular intima or
media. Individuals of advanced age, having diabetes mellitus or chronic kidney disease …

Diabetes mellitus to accelerated atherosclerosis: Shared cellular and molecular mechanisms in glucose and lipid metabolism

N Zhao, X Yu, X Zhu, Y Song, F Gao, B Yu… - Journal of Cardiovascular …, 2024 - Springer
Diabetes is one of the critical independent risk factors for the progression of cardiovascular
disease, and the underlying mechanism regarding this association remains poorly …

Phenotypic plasticity of vascular smooth muscle cells in vascular calcification: Role of mitochondria

YZ Liu, ZX Li, LL Zhang, D Wang… - Frontiers in Cardiovascular …, 2022 - frontiersin.org
Vascular calcification (VC) is an important hallmark of cardiovascular disease, the osteo-
/chondrocyte phenotype differentiation of vascular smooth muscle cells (VSMCs) is the main …

Construction of the circRNA‐miRNA‐mRNA Regulatory Network of an Abdominal Aortic Aneurysm to Explore Its Potential Pathogenesis

H Zhang, C Bian, S Tu, F Yin, P Guo, J Zhang… - Disease …, 2021 - Wiley Online Library
Background. Abdominal aortic aneurysm (AAA) is a progressive cardiovascular disease,
which is a permanent and localized dilatation of the abdominal aorta with potentially fatal …