The sirtuin family in health and disease

QJ Wu, TN Zhang, HH Chen, XF Yu, JL Lv… - … and Targeted Therapy, 2022 - nature.com
Sirtuins (SIRTs) are nicotine adenine dinucleotide (+)-dependent histone deacetylases
regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in …

[HTML][HTML] Obesity: a chronic low-grade inflammation and its markers

D Khanna, S Khanna, P Khanna, P Kahar, BM Patel - Cureus, 2022 - ncbi.nlm.nih.gov
As the prevalence of obesity continues to rise, the world is facing a major public health
concern. Obesity is a complex disease associated with an increase in several inflammatory …

Randomized controlled trial for time-restricted eating in healthy volunteers without obesity

Z Xie, Y Sun, Y Ye, D Hu, H Zhang, Z He… - Nature …, 2022 - nature.com
Time-restricted feeding (TRF) improves metabolic health. Both early TRF (eTRF, food intake
restricted to the early part of the day) and mid-day TRF (mTRF, food intake restricted to the …

Regulation of cholesterol homeostasis in health and diseases: from mechanisms to targeted therapeutics

Y Duan, K Gong, S Xu, F Zhang, X Meng… - Signal Transduction and …, 2022 - nature.com
Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Ultra-processed foods and human health: from epidemiological evidence to mechanistic insights

B Srour, MC Kordahi, E Bonazzi… - The lancet …, 2022 - thelancet.com
Epidemiological studies have suggested a role for ultra-processed foods in numerous
chronic inflammatory diseases such as inflammatory bowel diseases and metabolic …

Obesity and diabetes as high‐risk factors for severe coronavirus disease 2019 (Covid‐19)

Y Zhou, J Chi, W Lv, Y Wang - Diabetes/metabolism research …, 2021 - Wiley Online Library
The outbreak of the coronavirus disease 2019 (Covid‐19) has become an evolving
worldwide health crisis. With the rising prevalence of obesity and diabetes has come an …

Hippocampus and its involvement in Alzheimer's disease: a review

YL Rao, B Ganaraja, BV Murlimanju, T Joy… - 3 Biotech, 2022 - Springer
Hippocampus is the significant component of the limbic lobe, which is further subdivided into
the dentate gyrus and parts of Cornu Ammonis. It is the crucial region for learning and …

Metabolic syndrome pathophysiology and predisposing factors

A Bovolini, J Garcia, MA Andrade… - International journal of …, 2021 - thieme-connect.com
Metabolic syndrome (MetS) is a cluster of cardiometabolic risk factors with high prevalence
among adult populations and elevated costs for public health systems worldwide. Despite …

[HTML][HTML] Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance

J Wang, L Li, Z Zhang, X Zhang, Y Zhu, C Zhang, Y Bi - Cell metabolism, 2022 - cell.com
Type 2 diabetes with obesity-related insulin resistance as the main manifestation is
associated with an increased risk of cognitive impairment. Adipose tissue plays an important …

Tissue homeostasis and inflammation

ML Meizlish, RA Franklin, X Zhou… - Annual review of …, 2021 - annualreviews.org
There is a growing interest in understanding tissue organization, homeostasis, and
inflammation. However, despite an abundance of data, the organizing principles of tissue …