Mu-Opioid receptor biased ligands: A safer and painless discovery of analgesics?
A Madariaga-Mazón, AF Marmolejo-Valencia, Y Li… - Drug discovery today, 2017 - Elsevier
Highlights•μ-OR biased agonists represent promising analgesics with improved therapeutic
profiles.•Protein-ligand interactions might account for biased ligands functional …
profiles.•Protein-ligand interactions might account for biased ligands functional …
Opioid receptors and protonation-coupled binding of opioid drugs
Opioid receptors are G-protein-coupled receptors (GPCRs) part of cell signaling paths of
direct interest to treat pain. Pain may associate with inflamed tissue characterized by acidic …
direct interest to treat pain. Pain may associate with inflamed tissue characterized by acidic …
Structure and dynamics of dynorphin peptide and its receptor
Dynorphin is a neuropeptide involved in pain, addiction and mood regulation. It exerts its
activity by binding to the kappa opioid receptor (KOP) which belongs to the large family of G …
activity by binding to the kappa opioid receptor (KOP) which belongs to the large family of G …
Ligand/kappa-opioid receptor interactions: insights from the X-ray crystal structure
K Martinez-Mayorga, KG Byler, AB Yongye… - European journal of …, 2013 - Elsevier
During the past five years, the three-dimensional structures of 14 different G-protein coupled
receptors (GPCRs) have been resolved by X-ray crystallography. The most recently …
receptors (GPCRs) have been resolved by X-ray crystallography. The most recently …