[HTML][HTML] Targeted therapy in chronic diseases using nanomaterial-based drug delivery vehicles

AP Singh, A Biswas, A Shukla, P Maiti - Signal transduction and …, 2019 - nature.com
The application of nanomedicines is increasing rapidly with the promise of targeted and
efficient drug delivery. Nanomedicines address the shortcomings of conventional therapy, as …

Biomarkers of Parkinson's disease: present and future

DB Miller, JP O'Callaghan - Metabolism, 2015 - Elsevier
Sporadic or idiopathic Parkinson's disease (PD) is an age-related neurodegenerative
disorder of unknown origin that ranks only second behind Alzheimer's disease (AD) in …

[HTML][HTML] Ultrasound trapping and navigation of microrobots in the mouse brain vasculature

A Del Campo Fonseca, C Glück, J Droux… - Nature …, 2023 - nature.com
The intricate and delicate anatomy of the brain poses significant challenges for the treatment
of cerebrovascular and neurodegenerative diseases. Thus, precise local drug delivery in …

Recent advancements of nanomedicine in neurodegenerative disorders theranostics

S Mukherjee, VS Madamsetty… - Advanced Functional …, 2020 - Wiley Online Library
Recent times have witnessed an upsurge in the incidence of neurodegenerative disorders
such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Prion disease, and …

Intranasal nanotherapeutics for brain targeting and clinical studies in Parkinson's disease

P Saha, H Kathuria, MM Pandey - Journal of Controlled Release, 2023 - Elsevier
Parkinson's disease (PD) is the second leading neurodegenerative disease globally,
impacting the quality of life of millions of people. It is estimated that the treatment cost of PD …

Intranasal delivery of rotigotine to the brain with lactoferrin-modified PEG-PLGA nanoparticles for Parkinson's disease treatment

C Bi, A Wang, Y Chu, S Liu, H Mu, W Liu… - International journal …, 2016 - Taylor & Francis
Sustainable and safe delivery of brain-targeted drugs is highly important for successful
therapy in Parkinson's disease (PD). This study was designed to formulate biodegradable …

Novel focused ultrasound gene therapy approach noninvasively restores dopaminergic neuron function in a rat Parkinson's disease model

BP Mead, N Kim, GW Miller, D Hodges… - Nano …, 2017 - ACS Publications
Therapies capable of decelerating, or perhaps even halting, neurodegeneration in
Parkinson's disease (PD) remain elusive. Clinical trials of PD gene therapy testing the …

[HTML][HTML] Resveratrol brain delivery for neurological disorders prevention and treatment

S Andrade, MJ Ramalho, MC Pereira… - Frontiers in …, 2018 - frontiersin.org
Resveratrol (RES) is a natural polyphenolic non-flavonoid compound present in grapes,
mulberries, peanuts, rhubarb and in several other plants. Numerous health effects have …

Delivery of dual drug loaded lipid based nanoparticles across the blood–brain barrier impart enhanced neuroprotection in a rotenone induced mouse model of …

P Kundu, M Das, K Tripathy… - ACS chemical …, 2016 - ACS Publications
Parkinson's disease (PD) is the most widespread form of dementia where there is an age
related degeneration of dopaminergic neurons in the substantia nigra region of the brain …

In vitro and in vivo evaluation of levodopa-loaded nanoparticles for nose to brain delivery

S Arisoy, O Sayiner, T Comoglu, D Onal… - Pharmaceutical …, 2020 - Taylor & Francis
Parkinson's disease (PD) is a neurodegenerative disease which is characterized by the loss
of dopaminergic neurons in the brain. Levodopa is the drug of choice in the treatment of PD …