Azole fungicides are widely used chemicals in agriculture and medicine. Their antifungal
activity involves inhibition of steroid biosynthesis via inhibition of several cytochrome p450 …

Zebrafish (Danio rerio) is extensively used in research; however the mechanisms that
control this species sex determination are still poorly understood. In the latest decades, it …

Endocrine disrupting chemicals (EDCs) are exogenous chemicals that may occur naturally
(eg, phytoestrogens), while others are industrial substances and plasticizers commonly …

Over the past 25 years, extensive research in vertebrate species has identified several
genomic pathways altered by exposures to anthropogenic chemicals with hormone-like …

Aromatase (encoded by the cyp19a1a and cyp19a1b genes) plays a central role in sex
differentiation in fish, but its precise roles during sex differentiation are still largely unknown …

Fish sex ratio (SR) is an endpoint potentially indicating both endocrine activity and adversity,
essential elements for identifying Endocrine Disrupting Chemicals (EDCs) as required by …

Intersex in fish downstream of municipal wastewater treatment plants (MWWTPs) is a global
concern. Consistent high rates of intersex in male rainbow darter (Etheostoma caeruleum) …

Background Sex hormones play important roles in teleost ovarian and testicular
development. In zebrafish, ovarian differentiation appears to be dictated by an oocyte …

Pharmaceuticals and personal care products (PPCPs) as emerging contaminants are
ubiquitously present in the aquatic environment. Using in vivo and in silico techniques, this …

The lack of adequate strategies for monitoring endocrine disrupting compounds (EDCs) in
the aquatic environment is emphasized in the European Water Framework Directive. In this …