Pancreatic ductal adenocarcinoma (PDAC) belongs to the most lethal solid tumors in
humans. A histological hallmark feature of PDAC is the pronounced tumor microenvironment …

Connective tissue growth factor, also known as CCN2, is a cysteine-rich matricellular protein
involved in the control of biological processes, such as cell proliferation, differentiation …

Connective tissue growth factor (CTGF) is a key signaling and regulatory molecule involved
in different biological processes, such as cell proliferation, angiogenesis, and wound …

CTGF is a secreted matricellular protein with very complex biology. It has been shown to
modulate many signaling pathways leading to cell adhesion and migration, angiogenesis …

The YAP transcription coactivator has been implicated as an oncogene and is amplified in
human cancers. Recent studies have established that YAP is phosphorylated and inhibited …

Members of the CCN family of matricellular proteins are crucial for embryonic development
and have important roles in inflammation, wound healing and injury repair in adulthood …

We have identified a new role for the matrix enzyme lysyl oxidase–like-2 (LOXL2) in the
creation and maintenance of the pathologic microenvironment of cancer and fibrotic …

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor survival rates
and frequently carries oncogenic KRAS mutation. However, KRAS has thus far not been a …

We have used homologous recombination in ES cells to engineer B cell-deficient mice that
are incapable of expressing endogenous immunoglobulin heavy and kappa light chain …

Pancreatic stellate cells (PaSCs) are myofibroblast-like cells found in the areas of the
pancreas that have exocrine function. PaSCs are regulated by autocrine and paracrine …