The stringent response is a stress signalling system mediated by the alarmones guanosine
tetraphosphate (ppGpp) and guanosine pentaphosphate (pppGpp) in response to nutrient …

Temperature impacts biological systems across all length and timescales. Cells and the
enzymes that comprise them respond to temperature fluctuations on short timescales, and …

Timely adaptation to nutrient downshift is crucial for bacteria to maintain fitness during feast
and famine cycle in the natural niche. However, the molecular mechanism that ensures the …

Highlights●Why biofuels and bioproducts remain critical to society●What molecular
products can be made by biotechnology using available feedstocks●How new systems and …

Ribosome and protein synthesis lie at the core of cell growth and are major consumers of
the cellular budget. Here we review recent progress in the coupling of ribosome synthesis …

If biomanufacturing can become a sustainable route for producing chemicals, it will provide
a critical step in reducing greenhouse gas emissions to fight climate change. However …

Growth and environmental responses are essential for living organisms to survive and adapt
to constantly changing environments. In order to simulate new conditions and capture …

The emergence of antibiotic tolerance (prolonged survival against exposure) in natural
bacterial populations is a major concern. Since it has been studied primarily in isogenic …

Highlights•Limitations in molecular resources for gene expression influence bacterial
physiology.•Bacteria optimise trade-offs between resource allocation and growth.•Resource …

Bacteria must rapidly respond to both intracellular and environmental changes to survive.
One critical mechanism to rapidly detect and adapt to changes in environmental conditions …