Balancing the AspC and AspA Pathways of Escherichia coli by Systematic Metabolic Engineering Strategy for High-Efficient l-Homoserine Production

Y Chen, L Huang, T Yu, Y Yao, M Zhao… - ACS Synthetic …, 2024 - ACS Publications
l-Homoserine is a promising C4 platform compound used in the agricultural, cosmetic, and
pharmaceutical industries. Numerous works have been conducted to engineer Escherichia …

Survival of Escherichia coli after high-antibiotic stress is dependent on both the pregrown physiological state and incubation conditions

LB Thorfinnsdottir, GH Bø, JA Booth… - Frontiers in …, 2023 - frontiersin.org
Introduction The survival of bacterial cells exposed to antibiotics depends on the mode of
action, the antibiotics concentration, and the duration of treatment. However, it also depends …

The secondary messenger ppGpp interferes with cAMP-CRP regulon by promoting CRP acetylation in Escherichia coli

C Ro, M Cashel, L Fernández-Coll - PLoS One, 2021 - journals.plos.org
The cAMP-CRP regulon coordinates transcription regulation of several energy-related
genes, the lac operon among them. Lactose, or IPTG, induces the lac operon expression by …

Growth consequences of the inhomogeneous organization of the bacterial cytoplasm

JH van Heerden, A Berkvens, DH de Groot… - BioRxiv, 2023 - biorxiv.org
In many bacteria, translating ribosomes are excluded from the nucleoid, while amino-acid
and energy-supplying metabolic enzymes spread evenly throughout the cytoplasm. Here we …

Water-soluble humic materials modulating metabolism and triggering stress defense in Sinorhizobium fredii

X Qiu, T Gao, J Yang, E Wang, L Liu… - Microbiology …, 2021 - Am Soc Microbiol
Bacteria have evolved a series of mechanisms to maintain their survival and reproduction in
changeable and stressful environments. In-depth understanding of these mechanisms can …

Sex-Specific Effects of Polystyrene Microplastic and Lead (II) Co-Exposure on the Gut Microbiome and Fecal Metabolome in C57BL/6 Mice

W Shen, M Zhao, W Xu, X Shi, F Ren, P Tu, N Gao… - Metabolites, 2024 - mdpi.com
The wide spread of microplastics has fueled growing public health concern globally. Due to
their porous structure and large surface area, microplastics can serve as carriers for other …

Microbeads as carriers for Bacillus pumilus: a biofertilizer focus on auxin production

SV Benítez, R Carrasco, JD Giraldo… - Journal of …, 2024 - Taylor & Francis
The study aimed to develop a solid biofertilizer using Bacillus pumilus, focusing on auxin
production to enhance plant drought tolerance. Methods involved immobilising B. pumilus in …

The interplay between growth rate and nutrient quality defines gene expression capacity

J Kim, APS Darlington, DG Bates, JI Jimenez - BioRxiv, 2021 - biorxiv.org
The gene expression capacity of bacterial cells depends on the interplay between growth
and the availability of the transcriptional and translational machinery. Growth rate is widely …

Studies on the Regulation of (p)ppGpp Metabolism and Its Perturbation Through the Over-Expression of Nudix Hydrolases in Escherichia coli

R Sanyal, A Vimala, R Harinarayanan - Frontiers in Microbiology, 2020 - frontiersin.org
Stringent response mediated by modified guanosine nucleotides is conserved across
bacteria and is regulated through the Rel/Spo functions. In Escherichia coli, RelA and SpoT …

Control of ribosome synthesis in bacteria: the important role of rRNA chain elongation rate

M Zhu, H Mu, M Jia, L Deng, X Dai - Science China Life sciences, 2021 - Springer
Bacteria growth depends crucially on protein synthesis, which is limited by ribosome
synthesis. Ribosomal RNA (rRNA) transcription is the rate-limiting step of ribosome …