The development of an organism depends on intrinsic genetic programs of progenitor cells
and their spatiotemporally complex extrinsic environment. Ex vivo generation of organoids …

Multicellular organisms generate tissues of diverse shapes and functions from cells and
extracellular matrices. Their adhesion molecules mediate cell-cell and cell-matrix …

Immune cells rely on transient physical interactions with other immune and non-immune
populations to regulate their function. To study these 'kiss-and-run'interactions directly in …

Rationale: In the bone marrow microenvironment (BMME), mesenchymal stem/stromal cells
(MSCs) control the self-renewal of both healthy and cancerous hematopoietic …

Breakthroughs in precision cell surface engineering tools are supporting the rapid
development of programmable living assemblies with valuable features for tackling complex …

ABSTRACT A milestone in the field of recombinant binding molecules was achieved 30
years ago with the discovery of single-domain antibodies from which antigen-binding …

Synthetic cells are artificial constructs that mimic the structures and functions of living cells.
They are attractive for studying diverse biochemical processes and elucidating the origins of …

Cellular interactions are essential for tissue organization and functionality. In particular,
immune cells rely on direct and usually transient interactions with other immune and non …

Design in synthetic biology is typically goal oriented, aiming to repurpose or optimize
existing biological functions, augmenting biology with new-to-nature capabilities, or creating …

Large osseous void, postsurgical neoplastic recurrence, and slow bone-cartilage repair rate
raise an imperative need to develop functional scaffold in clinical osteosarcoma treatment …