Excess reactive oxygen species production by mitochondria is a key mechanism of age-
related vascular dysfunction. Our laboratory has shown that supplementation with the …

The NFE2L2 gene encodes the transcription factor Nrf2 best known for regulating the
expression of antioxidant and detoxification genes. Gene knockout approaches have …

Despite the success of renin-angiotensin system (RAS) blockade by angiotensin-converting
enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT1R) blockers, current …

The formula for survival in resuscitation describes educational efficiency and local
implementation as key determinants in survival after cardiac arrest. Current educational …

Aims To investigate whether metabolic signature composed of multiple plasma metabolites
can be used to characterize adherence and metabolic response to the Mediterranean diet …

Cardiac arrest effectiveness trials have traditionally reported outcomes that focus on
survival. A lack of consistency in outcome reporting between trials limits the opportunities to …

Cardiovascular disease (CVD) is the leading global cause of death, accounting for 17.3
million deaths per year. Preventive treatment that reduces CVD by even a small percentage …

Overall hypertension prevalence has not changed in the United States in recent decades
although awareness, treatment, and control improved. However, hypertension epidemiology …

Metformin is the most commonly prescribed drug for type 2 diabetes mellitus. In recent years,
in addition to glucose lowering, several studies have presented evidence suggesting some …

Sudden cardiac death (SCD) represents about 25% of deaths in clinical cardiology. The
identification of risk factors for SCD is the philosopher's stone of cardiology and the …