RNA-binding proteins in cancer: functional and therapeutic perspectives

D Kang, Y Lee, JS Lee - Cancers, 2020 - mdpi.com
Simple Summary RNA-binding proteins (RBPs) play central roles in regulating
posttranscriptional expression of genes. Many of them are known to be deregulated in a …

RNA m6A methylation in cancer

Z Wang, J Zhou, H Zhang, L Ge, J Li… - Molecular …, 2023 - Wiley Online Library
N 6‐methyladenosine (m6A) is one of the most abundant internal modifications in eukaryotic
messenger RNAs (mRNAs) and non‐coding RNAs (ncRNAs). It is a reversible and dynamic …

Prognostic prediction using a stemness index-related signature in a cohort of gastric cancer

X Chen, D Zhang, F Jiang, Y Shen, X Li… - Frontiers in molecular …, 2020 - frontiersin.org
Background With characteristic self-renewal and multipotent differentiation, cancer stem
cells (CSCs) have a crucial influence on the metastasis, relapse and drug resistance of …

JUN-induced super-enhancer RNA forms R-loop to promote nasopharyngeal carcinoma metastasis

Q Jia, Y Tan, Y Li, Y Wu, J Wang, F Tang - Cell Death & Disease, 2023 - nature.com
Oncogenic super-enhancers (SEs) generate noncoding enhancer/SE RNAs
(eRNAs/seRNAs) that exert a critical function in malignancy through powerful regulation of …

Upregulation of LINC00501 by H3K27 acetylation facilitates gastric cancer metastasis through activating epithelial‐mesenchymal transition and angiogenesis

R Dou, L Han, C Yang, Y Fang, J Zheng… - Clinical and …, 2023 - Wiley Online Library
Background The molecular mechanism of the significant role of long noncoding RNAs
(lncRNAs) in the progression and metastasis of gastric cancer (GC) remains largely elusive …

Expression and prognostic value of CDK1, CCNA2, and CCNB1 gene clusters in human breast cancer

Z Xing, X Wang, J Liu, M Zhang… - Journal of …, 2021 - journals.sagepub.com
Objective Cell cycle-associated proteins play important roles in breast cancer (BRCA),
based on evidence from cell lines, preclinical murine models, and human tissue samples …

Bioinformatics analysis of key genes and circRNA‐miRNA‐mRNA regulatory network in gastric cancer

Y Tian, Y Xing, Z Zhang, R Peng… - BioMed research …, 2020 - Wiley Online Library
Gastric cancer (GC) is one of the most common malignancies in the world, with morbidity
and mortality ranking second among all cancers. Accumulating evidences indicate that …

Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA

M Zhao, Y Wang, F Tan, L Liu, X Hou, C Fan… - Science China Life …, 2022 - Springer
Nasopharyngeal carcinoma (NPC) is a malignant tumor that usually occurs in people from
Southeast Asia and Southern China. NPC is prone to migration and invasion, leading to …

Drug delivery approaches for HuR-targeted therapy for lung cancer

R Raguraman, S Shanmugarama, M Mehta… - Advanced drug delivery …, 2022 - Elsevier
Lung cancer (LC) is often diagnosed at an advanced stage and conventional treatments for
disease management have limitations associated with them. Novel therapeutic targets are …

PTEN, a barrier for proliferation and metastasis of gastric cancer cells: from molecular pathways to targeting and regulation

M Ashrafizadeh, M Najafi, HL Ang, ER Moghadam… - Biomedicines, 2020 - mdpi.com
Cancer is one of the life-threatening disorders that, in spite of excellent advances in
medicine and technology, there is no effective cure for. Surgery, chemotherapy, and …