Molecular engines, therapeutic targets, and challenges in pediatric brain tumors: a special emphasis on hydrogen sulfide and RNA-based nano-delivery

SA Fahmy, A Dawoud, YA Zeinelabdeen, CJ Kiriacos… - Cancers, 2022 - mdpi.com
Simple Summary Pediatric brain tumors represent a formidable challenge in the field of
oncology. Pediatric brain tumors are sub-classified into several molecular sub-types, where …

[HTML][HTML] Green extraction of essential oils from Pistacia lentiscus resins: Encapsulation into Niosomes showed improved preferential cytotoxic and apoptotic effects …

SA Fahmy, NK Sedky, A Ramzy… - Journal of Drug Delivery …, 2023 - Elsevier
The essential oils extracted from Pistacia lentiscus resins possess promising antiproliferative
effects against ovarian and breast cancer cells because of their high content of bioactive …

Oral delivery of psoralidin by mucoadhesive surface-modified bilosomes showed boosted apoptotic and necrotic effects against breast and lung cancer cells

RA Youness, AM Al-Mahallawi, FH Mahmoud, H Atta… - Polymers, 2023 - mdpi.com
This study aims to design and optimize chitosan-coated bilosomal formulations loaded with
psoralidin (Ps-CS/BLs) with improved physicochemical properties, oral bioavailability, and …

Natural polyphenol tannin-immobilized composites: rational design and versatile applications

X Guan, B Zhang, Z Wang, Q Han, M An… - Journal of Materials …, 2023 - pubs.rsc.org
Tannins, which are natural plant polyphenols, are widely used in different fields, especially
in biomedical applications due to their unique properties, including high abundance, low …

Box–Behnken design of thermo-responsive nano-liposomes loaded with a platinum (IV) anticancer complex: evaluation of cytotoxicity and apoptotic pathways in triple …

NK Sedky, M Braoudaki, NK Mahdy, K Amin… - Nanoscale …, 2023 - pubs.rsc.org
Herein, thermo-responsive liposomes (TLs) loaded with Asp (Asp/TLs) were produced by
self-assembling DPPC, DSPE-PEG2000, and cholesterol. The preparation variables were …

Retama monosperma chemical profile, green synthesis of silver nanoparticles, and antimicrobial potential: a study supported by network pharmacology and molecular …

MH Alyami, AM Fakhry, NM El Halfawy, SM Toto… - RSC …, 2023 - pubs.rsc.org
In this study, Retama monosperma extract (RME) was used for the green synthesis of silver
nanoparticles (RME-AgNPs). RME's phenolic profile was identified by liquid …

Co-Delivery of Ylang Ylang Oil of Cananga odorata and Oxaliplatin Using Intelligent pH-Sensitive Lipid-Based Nanovesicles for the Effective Treatment of Triple …

NK Sedky, NM Abdel-Kader, MY Issa… - International Journal of …, 2023 - mdpi.com
Smart pH-responsive niosomes loaded with either Oxaliplatin (Ox), Ylang ylang essential oil
(Y-oil), or co-loaded with both compounds (Ox-Y)(Ox@ NSs, Y@ NSs, and Ox-Y@ NSs …

Nedaplatin/Peganum harmala Alkaloids Co-Loaded Electrospun, Implantable Nanofibers: A Chemopreventive Nano-Delivery System for Treating and Preventing …

NK Sedky, KK Arafa, MMM Abdelhady, MY Issa… - Pharmaceutics, 2023 - mdpi.com
Currently, the main pillars in treating breast cancer involve tumorectomy pursued by
hormonal, radio, or chemotherapies. Nonetheless, these approaches exhibit severe adverse …

PEGylated Chitosan Nanoparticles Loaded with Betaine and Nedaplatin Hamper Breast Cancer: In Vitro and In Vivo Studies

SA Fahmy, A Ramzy, NM El Samaloty, NK Sedky… - ACS …, 2023 - ACS Publications
The current study investigates the anticancer effects of PEGylated chitosan nanoparticles
(CS NPs) coloaded with betaine (BT) and nedaplatin (ND) on breast adenocarcinoma (MCF …

Phytochemical profiling, cytotoxic, anti-migration, and anti-angiogenic potential of phenolic-rich fraction from Peganum harmala: in vitro and in ovo studies

H Kemel, L Benguedouar, D Boudjerda, S Menadi… - Medical Oncology, 2024 - Springer
Peganum harmala has been extensively employed in Algerian traditional medicine
practices. This study aimed to explore the impact of n-butanol (n-BuOH) extract sourced from …