NF-κB: at the borders of autoimmunity and inflammation
L Barnabei, E Laplantine, W Mbongo… - Frontiers in …, 2021 - frontiersin.org
The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …
functions and serves as a pivotal mediator of inflammatory response. In the first part of this …
NF‐κB signaling in inflammation and cancer
T Zhang, C Ma, Z Zhang, H Zhang, H Hu - MedComm, 2021 - Wiley Online Library
Since nuclear factor of κ‐light chain of enhancer‐activated B cells (NF‐κB) was discovered
in 1986, extraordinary efforts have been made to understand the function and regulating …
in 1986, extraordinary efforts have been made to understand the function and regulating …
Immunogenicity of Pfizer-BioNTech COVID-19 vaccine in patients with inborn errors of immunity
D Hagin, T Freund, M Navon, T Halperin, D Adir… - Journal of Allergy and …, 2021 - Elsevier
Background In mid-December 2020, Israel started a nationwide mass vaccination campaign
against coronavirus disease 2019 (COVID-19). In the first few weeks, medical personnel …
against coronavirus disease 2019 (COVID-19). In the first few weeks, medical personnel …
NF-κB signaling in inflammation
The transcription factor NF-κB regulates multiple aspects of innate and adaptive immune
functions and serves as a pivotal mediator of inflammatory responses. NF-κB induces the …
functions and serves as a pivotal mediator of inflammatory responses. NF-κB induces the …
Humoral and cellular response following vaccination with the BNT162b2 mRNA COVID-19 vaccine in patients affected by primary immunodeficiencies
D Amodio, A Ruggiero, M Sgrulletti, C Pighi… - Frontiers in …, 2021 - frontiersin.org
Mass SARS-Cov-2 vaccination campaign represents the only strategy to defeat the global
pandemic we are facing. Immunocompromised patients represent a vulnerable population at …
pandemic we are facing. Immunocompromised patients represent a vulnerable population at …
[HTML][HTML] Loss-of-function nuclear factor κB subunit 1 (NFKB1) variants are the most common monogenic cause of common variable immunodeficiency in Europeans
Background The genetic cause of primary immunodeficiency disease (PID) carries
prognostic information. Objective We conducted a whole-genome sequencing study …
prognostic information. Objective We conducted a whole-genome sequencing study …
Human transcription factor protein interaction networks
H Göös, M Kinnunen, K Salokas, Z Tan, X Liu… - Nature …, 2022 - nature.com
Transcription factors (TFs) interact with several other proteins in the process of
transcriptional regulation. Here, we identify 6703 and 1536 protein–protein interactions for …
transcriptional regulation. Here, we identify 6703 and 1536 protein–protein interactions for …
What did we learn from CTLA‐4 insufficiency on the human immune system?
N Mitsuiki, C Schwab, B Grimbacher - Immunological reviews, 2019 - Wiley Online Library
Summary Cytotoxic‐T‐lymphocyte‐antigen‐4 (CTLA‐4) is a negative immune regulator
constitutively expressed on regulatory T (Treg) cells and upregulated on activated T cells …
constitutively expressed on regulatory T (Treg) cells and upregulated on activated T cells …
Common variable immunodeficiency: more pathways than roads to Rome
XP Peng, A Caballero-Oteyza… - Annual Review of …, 2023 - annualreviews.org
Fifty years have elapsed since the term common variable immunodeficiency (CVID) was
introduced to accommodate the many and varied antibody deficiencies being identified in …
introduced to accommodate the many and varied antibody deficiencies being identified in …
Biochemically deleterious human NFKB1 variants underlie an autosomal dominant form of common variable immunodeficiency
Autosomal dominant (AD) NFKB1 deficiency is thought to be the most common genetic
etiology of common variable immunodeficiency (CVID). However, the causal link between …
etiology of common variable immunodeficiency (CVID). However, the causal link between …