Many drug oxidations and conjugations are mediated by a variety of cytochromes P450
(P450) and non-P450 enzymes in humans and non-human primates. These non-P450 …

Abstract Carboxylesterases (CES1 and CES2) and arylacetamide deacetylase (AADAC),
which are expressed primarily in the liver and/or gastrointestinal tract, hydrolyze drugs …

The cynomolgus monkey is a nonhuman primate that is often used for pharmacokinetic and
toxicokinetic studies of new chemical entities. Species differences in drug metabolism are …

Arylamine N-acetyltransferases (NATs) are drug-metabolizing enzymes essential for the
metabolism of endogenous substrates and xenobiotics, and their molecular characteristics …

In the present study, we established a quantitative western blotting method to measure the
expression level of recombinant serine hydrolases based on their catalytic mechanism …

Cynomolgus monkeys, used as an animal model to predict human pharmacokinetics,
occasionally show different oral absorption patterns to humans due to differences in their …

Backgrounds Macaca fascicularis (M. fascicularis) is a primate model organism that played
important role in studying human health. It is vital to better understand the similarity and …

Carboxylesterase (CES) is important for the detoxification of a wide range of drugs and
xenobiotics. In this study, the hepatic level of CES2 mRNA was examined in cynomolgus …

The cynomolgus macaque is an important nonhuman primate species in drug metabolism
studies, in part because of its evolutionary closeness to humans. Cytochromes P450 …

In contrast to a single human carboxylesterase 2 (CES2) isozyme (hCE2), three CES2
genes have been identified in cynomolgus monkeys: mfCES2A, mfCES2B, and mfCES2C …