Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease and is
emerging as the leading cause of cirrhosis, liver transplantation and hepatocellular …

Dendritic cells (DCs) exhibit a specialized antigen-presenting function and play crucial roles
in both innate and adaptive immune responses. Due to their ability to cross-present tumor …

Despite no apparent defects in T cell priming and recruitment to tumors, a large subset of T
cell rich tumors fail to respond to immune checkpoint blockade (ICB). We leveraged a …

Cancer cells evade T cell-mediated killing through tumour–immune interactions whose
mechanisms are not well understood,. Dendritic cells (DCs), especially type-1 conventional …

Microbial colonization of the mammalian intestine elicits inflammatory or tolerogenic T cell
responses, but the mechanisms controlling these distinct outcomes remain poorly …

Chronic non-healing wounds are a major complication of diabetes, which affects 1 in 10
people worldwide. Dying cells in the wound perpetuate the inflammation and contribute to …

Most clinically applied cancer immunotherapies rely on the ability of CD8+ cytolytic T cells to
directly recognize and kill tumour cells,–. These strategies are limited by the emergence of …

Harnessing mRNA–lipid nanoparticles (LNPs) to treat patients with cancer has been an
ongoing research area that started before these versatile nanoparticles were successfully …

As the professional antigen-presenting cells of the immune system, dendritic cells (DCs)
sense the microenvironment and shape the ensuing adaptive immune response. DCs can …

Conventional dendritic cells (cDCs) are professional antigen-presenting cells that control the
adaptive immune response. Their subsets and developmental origins have been intensively …