The prefrontal cortex (PFC) serves as the chief executive officer of the brain, controlling the
highest level cognitive and emotional processes. Its local circuits among glutamatergic …

This review integrates Fredrickson's broaden-and-build theory of positive emotions with
advances in affective neuroscience regarding plasticity in the neural circuitry of emotions to …

The personality trait of neuroticism refers to relatively stable tendencies to respond with
negative emotions to threat, frustration, or loss. Individuals in the population vary markedly …

Gene–environment interaction research in psychiatry is new, and is a natural ally of
neuroscience. Mental disorders have known environmental causes, but there is …

In this report, which is an update of a guideline published in 2002 (Bandelow et al. 2002,
World J Biol Psychiatry 3: 171), recommendations for the pharmacological treatment of …

Evidence from diverse literatures supports the viewpoint that two modes of self-regulation
exist, a lower-order system that responds quickly to associative cues of the moment and a …

Most depressed patients don't respond to their first drug treatment, and the reasons for this
treatment resistance remain enigmatic. Human studies implicate a polymorphism in the …

Abstract Neurons using serotonin (5-HT) as neurotransmitter and/or modulator have been
identified in the central nervous system in representatives from all vertebrate clades …

The authors performed a meta-analysis of studies examining the association between
polymorphisms in the 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene, including …

Although neurotrophins have been postulated to have antidepressant properties, their effect
on anxiety is not clear. We find that transgenic overexpression of the neurotrophin BDNF has …