Genetic deficiencies of early components of the classical complement activation pathway
(especially C1q, r, s, and C4) are the strongest monogenic causal factors for the prototypic …

The complement system (CS) includes more than 50 proteins and its main function is to
recognize and protect against foreign or damaged molecular components. Other …

Complement factor H (CFH) is the major inhibitor of the alternative pathway of the
complement system and is structurally related to beta2-glycoprotein I, which itself is known …

The complement system is a versatile part of our immune system. Various intersection points
of complement with other cells and molecules of the immune response are well described …

The immune complement and the coagulation systems are blood-based proteolytic
cascades that are activated by pathway-specific triggers, based on protein–protein …

Extracellular vesicles (EVs) are a heterogeneous population of vesicles composed of a lipid
bilayer that carry a large repertoire of molecules including proteins, lipids, and nucleic acids …

Neisseria meningitidis protects itself from complement-mediated killing by binding
complement factor H (FH). Previous studies associated susceptibility to meningococcal …

Whey proteins in bovine milk, as the most widely used nutritional components for infant
formulae, have been paid more attention. However, the phosphorylation of proteins in …

Complement is a key component of the innate immune defence and in addition forms a
bridge to the adaptive immune responses. As such complement is of vital importance for …

Background Inflammaging is a persistent, low− grade, sterile, nonresolving inflammatory
state, associated with the senescence of the immune system. Such condition downregulates …