[HTML][HTML] Doxorubicin and other anthracyclines in cancers: Activity, chemoresistance and its overcoming
Anthracyclines have been important and effective treatments against a number of cancers
since their discovery. However, their use in therapy has been complicated by severe side …
since their discovery. However, their use in therapy has been complicated by severe side …
Ecology and genomics of Actinobacteria: new concepts for natural product discovery
Actinobacteria constitute a highly diverse bacterial phylum with an unrivalled metabolic
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …
versatility. They produce most of the clinically used antibiotics and a plethora of other natural …
Marine actinomycetes, new sources of biotechnological products
SV Jagannathan, EM Manemann, SE Rowe… - Marine Drugs, 2021 - mdpi.com
The Actinomycetales order is one of great genetic and functional diversity, including diversity
in the production of secondary metabolites which have uses in medical, environmental …
in the production of secondary metabolites which have uses in medical, environmental …
Anthracyclines: biosynthesis, engineering and clinical applications
MB Hulst, T Grocholski, JJC Neefjes… - Natural Product …, 2022 - pubs.rsc.org
Covering: January 1995 to June 2021 Anthracyclines are glycosylated microbial natural
products that harbour potent antiproliferative activities. Doxorubicin has been widely used as …
products that harbour potent antiproliferative activities. Doxorubicin has been widely used as …
Application of Streptomyces Antimicrobial Compounds for the Control of Phytopathogens
S Pacios-Michelena, CN Aguilar Gonzalez… - … in Sustainable Food …, 2021 - frontiersin.org
One of the relevant problems in today's agriculture is related to phytopathogenic
microorganisms that cause between 30–40% of crop losses. Synthetic chemical pesticides …
microorganisms that cause between 30–40% of crop losses. Synthetic chemical pesticides …
[HTML][HTML] Activation of microbial secondary metabolic pathways: Avenues and challenges
B Baral, A Akhgari, M Metsä-Ketelä - Synthetic and Systems Biotechnology, 2018 - Elsevier
Microbial natural products are a tremendous source of new bioactive chemical entities for
drug discovery. Next generation sequencing has revealed an unprecedented genomic …
drug discovery. Next generation sequencing has revealed an unprecedented genomic …
Microbe-driven chemical ecology: past, present and future
In recent years, research in the field of Microbial Ecology has revealed the tremendous
diversity and complexity of microbial communities across different ecosystems. Microbes …
diversity and complexity of microbial communities across different ecosystems. Microbes …
Proliferation of antibiotic-resistant microorganisms and associated genes during composting: An overview of the potential impacts on public health, management and …
FN Ezugworie, VC Igbokwe, CO Onwosi - Science of the total environment, 2021 - Elsevier
Antibiotic residues together with non-antibiotic drugs and heavy metals act as a selective
pressure for the spread of antibiotic-resistant microorganisms (ARMs), antibiotic-resistant …
pressure for the spread of antibiotic-resistant microorganisms (ARMs), antibiotic-resistant …
Comparative and pangenomic analysis of the genus Streptomyces
Streptomycetes are highly metabolically gifted bacteria with the abilities to produce
bioproducts that have profound economic and societal importance. These bioproducts are …
bioproducts that have profound economic and societal importance. These bioproducts are …
Aerobic composting as an effective cow manure management strategy for reducing the dissemination of antibiotic resistance genes: an integrated meta-omics study
L Zhang, L Li, G Sha, C Liu, Z Wang, L Wang - Journal of hazardous …, 2020 - Elsevier
Livestock manure is considered as an important source for spreading antibiotic resistance
genes (ARGs) into the environment, and therefore poses a direct threat to public health …
genes (ARGs) into the environment, and therefore poses a direct threat to public health …