Oxidative stress and inflammation: elucidating mechanisms of smoking-attributable pathology for therapeutic targeting

TA Addissouky, IET El Sayed, MMA Ali, Y Wang… - Bulletin of the National …, 2024 - Springer
Background Tobacco smoking remains a major preventable cause of disease and death
worldwide. Combustible cigarettes release thousands of chemicals that can initiate …

[HTML][HTML] The role of RhoA/ROCK pathway in the ischemic stroke-induced neuroinflammation

W Lu, Z Chen, J Wen - Biomedicine & Pharmacotherapy, 2023 - Elsevier
It is widely known that ischemic stroke is the prominent cause of death and disability. To
date, neuroinflammation following ischemic stroke represents a complex event, which is an …

Intermittent fasting reduces neuroinflammation in intracerebral hemorrhage through the Sirt3/Nrf2/HO-1 pathway

S Dai, J Wei, H Zhang, P Luo, Y Yang, X Jiang… - Journal of …, 2022 - Springer
Background Inflammation contributes to the poor prognosis of intracerebral hemorrhage
(ICH). Intermittent fasting (IF) has been shown to be protective against inflammation in …

Shaping the future of cardiac wellness: exploring revolutionary approaches in disease management and prevention

TA Addissouky, IET El Sayed, MMA Ali… - Journal of Clinical …, 2024 - scientificarchives.com
Cardiovascular diseases (CVDs) remain a leading cause of morbidity and mortality
worldwide. Effective prevention and management strategies are essential to reduce the …

The dual function of microglial polarization and its treatment targets in ischemic stroke

Y Mo, W Xu, K Fu, H Chen, J Wen, Q Huang… - Frontiers in …, 2022 - frontiersin.org
Stroke is the leading cause of disability and death worldwide, with ischemic stroke occurring
in~ 5% of the global population every year. Recently, many studies have been conducted on …

Cyclo-(Phe-Tyr) as a novel cyclic dipeptide compound alleviates ischemic/reperfusion brain injury via JUNB/JNK/NF-κB and SOX5/PI3K/AKT pathways

J Cai, J Liang, Y Zhang, L Shen, H Lin, T Hu… - Pharmacological …, 2022 - Elsevier
Ischemic/reperfusion (IR) can cause adverse reactions including apoptosis, oxidative stress,
and inflammation, but the existing therapeutic strategies have been limited. Moreover, the …

Molecular pathways in sepsis pathogenesis: Recent advances and therapeutic avenues

TA Addissouky, IET El Sayed, MMA Ali… - Journal of Cellular …, 2024 - scientificarchives.com
Molecular Pathways in Sepsis Pathogenesis: Recent Advances and Therapeutic Avenues
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[PDF][PDF] Transforming toxicity assessment through microphysiology, bioprinting, and computational modeling

TA Addissouky, Y Wang… - Advances in Clinical …, 2024 - researchgate.net
Background: Traditional toxicity testing emphasizes animal models with growing concerns
regarding predictive capacity, throughput and ethics. Rapid innovation surrounding human …

[HTML][HTML] EEF1A1 is Involved the Regulating Neuroinflammatory Processes in Parkinson's Disease

Z Aisha, J Lei, Y Zhang, J Ma - Journal of Integrative Neuroscience, 2023 - imrpress.com
Background: Studies have reported that the RNA-binding protein Eukaryotic Elongation
Factor 1A1 (EEF1A1) is low expressed in the hippocampal region of Alzheimer's disease …

Blood–Brain Barrier‐Penetrating and Lesion‐Targeting Nanoplatforms Inspired by the Pathophysiological Features for Synergistic Ischemic Stroke Therapy

L Tang, Y Yin, H Liu, M Zhu, Y Cao, J Feng… - Advanced …, 2024 - Wiley Online Library
Ischemic stroke is a dreadful vascular disorder that poses enormous threats to the public
health. Due to its complicated pathophysiological features, current treatment options after …