Spotlight on photoactivatable liposomes beyond drug delivery: an enabler of multitargeting of molecular pathways

MA Saad, T Hasan - Bioconjugate chemistry, 2022 - ACS Publications
The potential of photoactivating certain molecules, photosensitizers (PS), resulting in
photochemical processes, has long been realized in the form of photodynamic therapy …

[HTML][HTML] Optimizing axial and peripheral substitutions in si-centered naphthalocyanine dyes for enhancing aqueous solubility and photoacoustic signal intensity

MA Saad, R Pawle, S Selfridge, L Contreras… - International Journal of …, 2023 - mdpi.com
Photoacoustic imaging using external contrast agents is emerging as a powerful modality for
real-time molecular imaging of deep-seated tumors. There are several chromophores, such …

Development and Evaluation of Targeted Optical Imaging Probes for Image‐Guided Surgery in Head and Neck Cancer

Y Wu, H Wu, X Lu, Y Chen, X Zhang, J Ju… - Advanced …, 2022 - Wiley Online Library
Head and neck cancer is the 7th most common cancer in the world and the primary
treatment is surgical resection. Optical probes have shown great potential for application in …

Photoimmunotherapy retains its anti-tumor efficacy with increasing stromal content in heterotypic pancreatic cancer spheroids

MA Saad, W Zhung, ME Stanley, S Formica… - Molecular …, 2022 - ACS Publications
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive disease characterized by
increased levels of desmoplasia that contribute to reduced drug delivery and poor treatment …

Hyaluronic acid-poly (lactic-co-glycolic acid) nanoparticles with a ruthenium photosensitizer cargo for photokilling of oral cancer cells

J Quílez-Alburquerque, MA Saad, AB Descalzo… - … of Photochemistry and …, 2023 - Elsevier
Photodynamic therapy (PDT), a combination of light, molecular oxygen and a
photosensitizing dye, has gained attention as a promising technique to treat various types of …

[HTML][HTML] A fluorescent photoimmunoconjugate for imaging of cholesteatoma

S Early, MA Saad, S Mallidi, A Mansour, R Seist… - Scientific Reports, 2022 - nature.com
Cholesteatoma is a potentially serious complication of chronic ear infections and requires
surgical intervention for definitive management. Long-term complications include a frequent …

EGFR-targeted multi-modal molecular imaging and treatment in a heterocellular model of head and neck cancer

MA Saad, L Contreras, S Bano… - … Technology in Head …, 2022 - spiedigitallibrary.org
Precision molecular imaging finds application in the delineation of tumor margins during
surgical resection of head and neck cancers (HNCs). Despite the advantages of surgery …

Dual-Function Antibody Conjugate-Enabled Photoimmunotherapy Complements Fluorescence and Photoacoustic Imaging of Head and Neck Cancer Spheroids

MA Saad, S Grimaldo-Garcia, A Sweeney… - Bioconjugate …, 2023 - ACS Publications
Several molecular-targeted imaging and therapeutic agents are in clinical trials for image-
guided surgery and photoimmunotherapy (PIT) for head and neck cancers. In this context …

[HTML][HTML] Enabling multi-modal imaging and photoimmunotherapy of oral cancer spheroids through an EGFR-targeted antibody conjugate

MA Saad, S Grimaldo-Garcia, L Contreras… - Photodiagnosis and …, 2024 - Elsevier
Significance Delineating tumor margins during surgery and eliminating residual disease is a
major challenge in the treatment of oral cancers. The dual function antibody conjugate …

Evaluating the imaging and therapeutic performance of a dual function antibody conjugate in head and neck cancer spheroids

MA Saad, S Grimaldo-Garcia, L Contreras… - … Probes, Imaging and …, 2023 - opg.optica.org
Conference title, upper and lower case, bolded, 18 point type, centered Page 1 Evaluating the
imaging and therapeutic performance of a dual function antibody conjugate in head and neck …