Natural polyphenols in cancer therapy

M Asensi, A Ortega, S Mena, F Feddi… - Critical reviews in …, 2011 - Taylor & Francis
Natural polyphenols are secondary metabolites of plants involved in defense against
different types of stress. Extracts containing these compounds have been used for …

[HTML][HTML] Insights on the effects of resveratrol and some of its derivatives in cancer and autoimmunity: a molecule with a dual activity

E Gianchecchi, A Fierabracci - Antioxidants, 2020 - mdpi.com
In recent years, the interest in natural compounds exerting immunoregulatory effects has
enormously increased. Among these, the polyphenol resveratrol, found in a variety of foods …

[HTML][HTML] The cinnamon-derived dietary factor cinnamic aldehyde activates the Nrf2-dependent antioxidant response in human epithelial colon cells

W GT, NF Villeneuve, SD Lamore, AS Bause, T Jiang… - Molecules, 2010 - mdpi.com
Colorectal cancer (CRC) is a major cause of tumor-related morbidity and mortality
worldwide. Recent research suggests that pharmacological intervention using dietary factors …

Chemopreventive effect of oleuropein in colitis‐associated colorectal cancer in c57bl/6 mice

E Giner, MC Recio, JL Ríos… - Molecular nutrition & …, 2016 - Wiley Online Library
Scope The main phenolic secoiridoid oleuropein and active constituent from olive tree (Olea
europaea, Oleaceae), has demonstrated anti‐inflammatory properties in intestinal …

Phase-II metabolism limits the antiproliferative activity of urolithins in human colon cancer cells

A Gonzalez-Sarrias, JA Giménez-Bastida… - European journal of …, 2014 - Springer
Purpose Urolithins, gut microbiota metabolites derived from ellagic acid and ellagitannins,
reach micromolar concentrations in the colon lumen where can have anti-inflammatory and …

The ellagic acid-derived gut microbiota metabolite, urolithin A, potentiates the anticancer effects of 5-fluorouracil chemotherapy on human colon cancer cells

A González-Sarrías, J Tomé-Carneiro, A Bellesia… - Food & function, 2015 - pubs.rsc.org
Chemotherapy increases the overall survival in colorectal cancer (CRC) patients. 5-
Fluorouracil (5-FU) remains as a drug of first choice in CRC therapy over the last four …

Gene expression, cell cycle arrest and MAPK signalling regulation in Caco‐2 cells exposed to ellagic acid and its metabolites, urolithins

A González‐Sarrías, JC Espín… - Molecular nutrition & …, 2009 - Wiley Online Library
Novel gene expression profiles and cellular functions modulated in Caco‐2 cells in
response to the dietary polyphenol, ellagic acid (EA), and its colonic metabolites, urolithin‐A …

Nrf2-dependent suppression of azoxymethane/dextran sulfate sodium–induced colon carcinogenesis by the cinnamon-derived dietary factor cinnamaldehyde

M Long, S Tao, M Rojo de la Vega, T Jiang… - Cancer Prevention …, 2015 - AACR
The progressive nature of colorectal cancer and poor prognosis associated with the
metastatic phase of the disease create an urgent need for the development of more …

[HTML][HTML] Anticancer effects of maple syrup phenolics and extracts on proliferation, apoptosis, and cell cycle arrest of human colon cells

A González-Sarrías, L Li, NP Seeram - Journal of Functional Foods, 2012 - Elsevier
The antiproliferative effects of Canadian maple syrup (grades C and D) extracts and fifty-one
purified phenolic constituents were evaluated against human tumourigenic (HT-29, HCT …

Effects of Maple (Acer) Plant Part Extracts on Proliferation, Apoptosis and Cell Cycle Arrest of Human Tumorigenic and Non‐tumorigenic Colon Cells

A González‐Sarrías, L Li, NP Seeram - Phytotherapy Research, 2012 - Wiley Online Library
Phenolic‐enriched extracts of maple sap and syrup, obtained from the sugar and red maple
species (Acer saccharum Marsh, A. rubrum L., respectively), are reported to show anticancer …