Amyotrophic lateral sclerosis (ALS) is a devastating disease caused by degeneration of
motor neurons. As with all major neurodegenerative disorders, development of disease …

Neurotransmitters are molecules that amplify, transmit, and convert signals in cells, having
an essential role in information transmission throughout the nervous system. Hundreds of …

Abstract Nuclear Factor-Erythroid Factor 2 (Nrf2) is an important transcription factor that
regulates the expression of large number of genes in healthy and disease states. Nrf2 is …

Mitochondrial dysfunction and axon loss are hallmarks of neurologic diseases. Gasdermin
(GSDM) proteins are executioner pore-forming molecules that mediate cell death, yet their …

The genetic underpinnings and end-stage pathological hallmarks of neurodegenerative
diseases are increasingly well defined, but the cellular pathophysiology of disease initiation …

The possible interconnection between the eye and central nervous system (CNS) has been
a topic of discussion for several years just based on fact that the eye is properly considered …

O-GlcNAcylation is a posttranslational modification that adds O-linked β-N-
acetylglucosamine (O-GlcNAc) to serine or threonine residues of many proteins. This protein …

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disorder
affecting upper and lower motor neurons, with death resulting mainly from respiratory failure …

The distinguishing pathogenic features of neurodegenerative diseases include
mitochondrial dysfunction and derived reactive oxygen species generation. The neural …

Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two related
currently incurable neurodegenerative diseases. ALS is characterized by degeneration of …