Mitochondrial biogenesis as a therapeutic target for traumatic and neurodegenerative CNS diseases
EC Simmons, NE Scholpa, RG Schnellmann - Experimental neurology, 2020 - Elsevier
Central nervous system (CNS) diseases, both traumatic and neurodegenerative, are
characterized by impaired mitochondrial bioenergetics and often disturbed mitochondrial …
characterized by impaired mitochondrial bioenergetics and often disturbed mitochondrial …
Aligned collagen scaffold combination with human spinal cord-derived neural stem cells to improve spinal cord injury repair
Neural stem/progenitor cell (NSPC)-based spinal cord injury (SCI) therapy is expected to
bridge the lesion site by transplanting exogenous NSPCs for replacement of lost cells. The …
bridge the lesion site by transplanting exogenous NSPCs for replacement of lost cells. The …
Challenges of stem cell therapy for spinal cord injury: human embryonic stem cells, endogenous neural stem cells, or induced pluripotent stem cells?
Spinal cord injury (SCI) causes myelopathy, damage to white matter, and myelinated fiber
tracts that carry sensation and motor signals to and from the brain. The gray matter damage …
tracts that carry sensation and motor signals to and from the brain. The gray matter damage …
Inhibition of NF-κB signaling pathway by resveratrol improves spinal cord injury
L Xu, BOA Botchway, S Zhang, J Zhou… - Frontiers in …, 2018 - frontiersin.org
Spinal cord injury (SCI) can have a significant impact on an individual's life. Herein, we
discuss how resveratrol improves SCI by inhibiting nuclear factor kappa-light-chain …
discuss how resveratrol improves SCI by inhibiting nuclear factor kappa-light-chain …
CSF1R inhibition reduces microglia proliferation, promotes tissue preservation and improves motor recovery after spinal cord injury
Spinal cord injury (SCI) induces a pronounced neuroinflammation driven by activation and
proliferation of resident microglia as well as infiltrating peripheral monocyte-derived …
proliferation of resident microglia as well as infiltrating peripheral monocyte-derived …
A clinical prediction model for long-term functional outcome after traumatic spinal cord injury based on acute clinical and imaging factors
JR Wilson, RG Grossman, RF Frankowski… - Journal of …, 2012 - liebertpub.com
To improve clinicians' ability to predict outcome after spinal cord injury (SCI) and to help
classify patients within clinical trials, we have created a novel prediction model relating …
classify patients within clinical trials, we have created a novel prediction model relating …
Endogenous neural stem cell responses to stroke and spinal cord injury
CA Grégoire, BL Goldenstein, EM Floriddia… - Glia, 2015 - Wiley Online Library
Stroke and spinal cord injury (SCI) are among the most frequent causes of central nervous
system (CNS) dysfunction, affecting millions of people worldwide each year. The personal …
system (CNS) dysfunction, affecting millions of people worldwide each year. The personal …
Tauroursodeoxycholic acid alleviates secondary injury in spinal cord injury mice by reducing oxidative stress, apoptosis, and inflammatory response
Y Hou, J Luan, T Huang, T Deng, X Li, Z Xiao… - Journal of …, 2021 - Springer
Background Tauroursodeoxycholic acid (TUDCA) is a hydrophilic bile acid derivative, which
has been demonstrated to have neuroprotective effects in different neurological disease …
has been demonstrated to have neuroprotective effects in different neurological disease …
Secreted ectodomain of sialic acid-binding Ig-like lectin-9 and monocyte chemoattractant protein-1 promote recovery after rat spinal cord injury by altering …
K Matsubara, Y Matsushita, K Sakai… - Journal of …, 2015 - Soc Neuroscience
Engrafted mesenchymal stem cells from human deciduous dental pulp (SHEDs) support
recovery from neural insults via paracrine mechanisms that are poorly understood. Here we …
recovery from neural insults via paracrine mechanisms that are poorly understood. Here we …
Mitochondrial-based therapeutics for the treatment of spinal cord injury: mitochondrial biogenesis as a potential pharmacological target
NE Scholpa, RG Schnellmann - Journal of Pharmacology and Experimental …, 2017 - ASPET
Spinal cord injury (SCI) is characterized by an initial trauma followed by a progressive
cascade of damage referred to as secondary injury. A hallmark of secondary injury is …
cascade of damage referred to as secondary injury. A hallmark of secondary injury is …