Dopamine (DA) acts as a key neurotransmitter in the brain. Numerous studies have shown
its regulatory role for motor and limbic functions. However, in the early stages of Parkinson's …

The neostriatum is the larges* component of the basal ganglia, and the main recipient of
afferents to the basal ganglia from the cerebral cortex and thalamus. Studies of the cellular …

The striatum and its ventral extension, the nucleus accumbens, are involved in behaviors as
diverse as motor planning, drug seeking, and learning. Invariably, these striatally mediated …

The application of modem molecular biological methods has had an increasing and
dramatic impact upon the discipline of molecular neuropharmacology. This is particularly …

A cDNA fragment homologous to other G protein-coupled receptors was isolated from rat
brain using the PCR method and demonstrated to be abundantly expressed in striatum …

The nucleus accumbens (NAc) is clearly implicated in reward processing and drug
addiction, as well as in numerous neurological and psychiatric disorders; nevertheless, the …

The modulatory actions of dopamine on the flow of cortical information through the basal
ganglia are mediated mainly through two subtypes of receptors, the D1 and D2 receptors. In …

Parkinson's disease is classically characterised as a motor neurodegenerative disorder.
Motor symptoms in the disorder are secondary to an altered dopamine–acetylcholine …

This chapter is an update on the dopamine (DA) imbalance in schizophrenia, including the
evidence for subcortical hyperstimulation of D2 receptors underlying positive symptoms and …

1. Tonically active neurons (TANs) in the primate striatum develop transient responses to
sensory conditioning stimuli during behavioral training in classical conditioning tasks. In this …