Pyrroles are among the most privileged and influential small N-heterocycles at the core of
many commercial drugs, biological composition, natural compounds, agrochemicals, and …

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Pair your accounts. Export articles to Mendeley Get article recommendations from ACS based …

Mitragynine (MG) is the most abundant alkaloid component of the psychoactive plant
material “kratom”, which according to numerous anecdotal reports shows efficacy in self …

A visible-light-induced radical acylation of imines with α-ketoacids has been achieved,
enabled by an electron-donor–acceptor (EDA) complex. This EDA complex-mediated …

Interactions of 21 fentanyl derivatives with μ-opioid receptor (μOR) were studied using
experimental and theoretical methods. Their binding to μOR was assessed with radioligand …

One of the main challenges in contemporary medicinal chemistry is the development of safer
analgesics, used in the treatment of pain. Currently, moderate to severe pain is still treated …

In this work, we studied a series of carfentanyl amide-based opioid derivatives targeting the
mu opioid receptor (μOR) and the delta opioid receptor (δOR) heteromer as a credible novel …

Automated, miniaturized and accelerated synthesis for efficient property optimization is a
formidable challenge in chemistry in the 21st century as it helps to reduce resources and …

The opioids have been used for more than a thousand years and are not only the most
widely prescribed drugs for moderate to severe pain and acute pain, but also the preferred …

Carfentanil, the most potent of the fentanyl analogues, is at the forefront of synthetic opioid-
related deaths, second to fentanyl. Moreover, the administration of the opioid receptor …