Opioids are currently the most effective and widely used painkillers in the world.
Unfortunately, the clinical use of opioid analgesics is limited by serious adverse effects …

The opioids have been used for more than a thousand years and are not only the most
widely prescribed drugs for moderate to severe pain and acute pain, but also the preferred …

Multicomponent reactions (MCRs) date back to the mid‐1800s and are widely used today as
they offer increased atom efficiency, high molecular diversity, and often heterocycle …

Isotopic labeling is an attractive modality that has been widely used in many aspects of
chemistry, the life sciences, and medical research; especially deuterated drugs and …

A catalytic asymmetric N-nitroso aldol reaction of alkenyl trifluoroacetates with nitrosoarenes
was achieved using a DTBM-SEGPHOS· AgOTf complex as the chiral precatalyst and …

Pain is a symptom of ninety percent of human diseases, and pain management is a very
important medicinal problem. Various modulators of the pain response have been detected …

A novel approach for the synthesis of the C1 and C3‐dialkoxy indoles has been developed
for using 2‐(phenylethynyl) aniline with formaldehyde and alcohols under the catalysis of …

It was previously reported that 6β-aminomorphinan derivatives show high affinity for opiate
receptors. Novel 6β-heteroarylamidomorphinanes were designed based on the MOR …

2017-12-19 Assigned to NATIONAL INSTITUTES OF HEALTH (NIH), US DEPT. OF HEALTH
AND HUMAN SERVICES (DHHS), US GOVERNMENT reassignment NATIONAL …

A number of novel sterol derivatives with dipeptide-like side chains were synthesized using
an Ugi four-component condensation method and assayed to test their anti-inflammatory …