This chapter focuses on the introduction of molecular signaling pathways involved in
regulating the toxicity of environmental toxicants or stresses in Caenorhabditis elegans …

Caenorhabditis elegans has been used as a major model organism to identify genetic
factors that regulate organismal aging and longevity. Insulin/insulin-like growth factor 1 (IGF …

A large amount of the longevity-modulating genes discovered during the last two decades
are highly conserved during evolution from yeast and invertebrates to mammals. Many …

Background The mitochondrial unfolded protein response (mitoUPR) is a stress response
pathway activated by disruption of proteostasis in the mitochondria. This pathway has been …

The metabolome represents a complex network of biological events that reflects the
physiologic state of the organism in health and disease. Additionally, specific metabolites …

We review the findings that establish that perturbations of various aspects of mitochondrial
function, including oxidative phosphorylation, can promote lifespan extension, with different …

Paraquat (methyl viologen), is a non-selective contact herbicide and well known
mitochondrial toxicant. Mitochondria are the center of cellular metabolism, and involved in …

While mitochondrial function is essential for life in all multicellular organisms, a mild
impairment of mitochondrial function can extend longevity in model organisms. By …

The nematode Caenorhabditis elegans was introduced as a model organism in biological
research by Sydney Brenner in the 1970s. Since then, it has been increasingly used for …

Key discoveries in aging research have been made possible with the use of model
organisms. Caenorhabditis elegans is a short-lived nematode that has become a well …