Genetic basis of enhanced stress resistance in long‐lived mutants highlights key role of innate immunity in determining longevity

SK Soo, A Traa, ZD Rudich, A Moldakozhayev… - Aging …, 2023 - Wiley Online Library
Mutations that extend lifespan are associated with enhanced resistance to stress. To better
understand the molecular mechanisms underlying this relationship, we directly compared …

Piquiá Shells (Caryocar villosum): A Fruit by‐Product with Antioxidant and Antiaging Properties in Caenorhabditis elegans

M Roxo, H Peixoto, P Wetterauer… - … medicine and cellular …, 2020 - Wiley Online Library
In a context of rising demand for sustainable antiaging interventions, fruit processing by‐
products are a promising source of bioactive compounds for the production of antiaging …

Dendrobium Nobile Alcohol Extract Extends the Lifespan of Caenorhabditis elegans via hsf-1 and daf-16

L Li, Z Liu, H Hu, R Cai, J Bi, Q Wang, X Zhou, H Luo… - Molecules, 2024 - mdpi.com
Dendrobium nobile is a traditional Chinese herb with anti-inflammatory, antioxidant, and
neuroprotective properties. However, its antiaging effects are unclear. Herein, we studied …

Effect of Auricularia auricula fermentation broth on the liver and stomach of mice with acute alcoholism

X Yu, R Wang, B Lai, M Tan - Food & function, 2021 - pubs.rsc.org
In this paper, the protective effect of Auricularia auricula (A. auricula) fermentation broth on
the liver and stomach of mice with acute alcoholism was studied. The A. auricula …

Ag2Se quantum dots damage the nervous system of nematode Caenorhabditis elegans

X Liang, X Wang, J Cheng, X Zhang, T Wu - Bulletin of Environmental …, 2022 - Springer
Silver selenide quantum dots (Ag2Se QDs), as a novel type of QDs, are valuable in the
biomedical application due to their low-toxic and excellent optical property in near infrared …

Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response

E Kim, A Annibal, Y Lee, HEH Park, S Ham… - Nature …, 2023 - nature.com
Accumulating evidence indicates that mitochondria play crucial roles in immunity. However,
the role of the mitochondrial Krebs cycle in immunity remains largely unknown, in particular …

Elevated Trehalose Levels in C. elegans daf-2 Mutants Increase Stress Resistance, Not Lifespan

M Rasulova, A Zečić, JM Monje Moreno… - Metabolites, 2021 - mdpi.com
The C. elegans insulin/IGF-1 (insulin-like growth factor 1) signaling mutant daf-2
recapitulates the dauer metabolic signature—a shift towards lipid and carbohydrate …

Overexpression of mitochondrial fission or mitochondrial fusion genes enhances resilience and extends longevity

A Traa, A Keil, A AlOkda, S Jacob‐Tomas… - Aging …, 2024 - Wiley Online Library
The dynamicity of the mitochondrial network is crucial for meeting the ever‐changing
metabolic and energy needs of the cell. Mitochondrial fission promotes the degradation and …

Silencing of the mitochondrial ribosomal protein L-24 gene activates the oxidative stress response in Caenorhabditis elegans

G Ficociello, E Schifano, M Di Nottia, A Torraco… - … et Biophysica Acta (BBA …, 2023 - Elsevier
The mitochondrial translation machinery allows the synthesis of the mitochondrial-encoded
subunits of the electron transport chain. Defects in this process lead to mitochondrial …

Extension of life span and stress tolerance modulated by DAF-16 in Caenorhabditis elegans under the treatment of Moringa oleifera extract

AP Chauhan, MG Chaubey, SN Patel, D Madamwar… - 3 Biotech, 2020 - Springer
The present study was focused to isolate the bioactive compounds present in the leaves of
Moringa oleifera which contains a high nutritional value. Furthermore, the research was …